Seroatlas · Human Serome Atlas

EIF4EBP2

Eukaryotic translation initiation factor 4E-binding protein 2

Also known as: 4EBP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13542
Gene: EIF4EBP2
Ensembl: ENSG00000148730
Chromosome: 10
Canonical length: 120 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>Q13542|EIF4EBP2
     1  MSSSAGSGHQ PSQSRAIPTR TVAISDAAQL PHDYCTTPGG TLFSTTPGGT RIIYDRKFLL
    61  DRRNSPMAQT PPCHLPNIPG VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQFEMDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4EBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 64 nTPM
tongue: 63 nTPM
skeletal muscle: 60 nTPM
kidney: 54 nTPM
liver: 47 nTPM
small intestine: 45 nTPM

Single-cell type

esophageal apical cells: 422 nCPM
enterocytes: 227 nCPM
thymic myoid cells: 201 nCPM
hepatocytes: 201 nCPM
extravillous trophoblasts: 192 nCPM
neutrophil progenitors: 189 nCPM

Immune cell

eosinophil: 29 nTPM
non-classical monocyte: 23 nTPM
neutrophil: 21 nTPM
basophil: 21 nTPM
classical monocyte: 19 nTPM
total PBMC: 19 nTPM

Brain region

thalamus: 79 nTPM
medulla oblongata: 66 nTPM
choroid plexus: 65 nTPM
amygdala: 63 nTPM
midbrain: 62 nTPM
basal ganglia: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0.31
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF4EBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF4EBP2 as an antibody target. Whether an autoantibody or antibody against EIF4EBP2 could matter depends on whether native EIF4EBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF4EBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF4EBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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