Seroatlas · Human Serome Atlas

LAMTOR5

Ragulator complex protein LAMTOR5

Also known as: HBXIP, LTOR5_HUMAN, MGC71071, XIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43504
Gene: LAMTOR5
Ensembl: ENSG00000134248
Chromosome: 1
Canonical length: 91 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

91 residues, UniProt reviewed canonical sequence.

>O43504|LAMTOR5
     1  MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ QAAKLTSDPT
    61  DIPVVCLESD NGNIMIQKHD GITVAVHKMA S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMTOR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 431 nTPM

Expression across tissuesHPA

Tissue

kidney: 431 nTPM
heart muscle: 265 nTPM
skeletal muscle: 260 nTPM
tongue: 259 nTPM
bone marrow: 236 nTPM
choroid plexus: 209 nTPM

Single-cell type

oocytes: 898 nCPM
esophageal apical cells: 666 nCPM
parietal cells: 631 nCPM
syncytiotrophoblasts: 567 nCPM
hofbauer cells: 558 nCPM
esophageal suprabasal cells: 557 nCPM

Immune cell

eosinophil: 487 nTPM
neutrophil: 350 nTPM
memory B-cell: 346 nTPM
naive B-cell: 324 nTPM
plasmacytoid DC: 322 nTPM
basophil: 297 nTPM

Brain region

choroid plexus: 100 nTPM
cerebellum: 99 nTPM
white matter: 98 nTPM
spinal cord: 94 nTPM
hypothalamus: 90 nTPM
thalamus: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: -0.91
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ragulator complex protein LAMTOR5
Ragulator complex protein LAMTOR5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAMTOR5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAMTOR5 as an antibody target. Whether an autoantibody or antibody against LAMTOR5 could matter depends on whether native LAMTOR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAMTOR5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LAMTOR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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