Seroatlas · Human Serome Atlas

AKT1S1

Proline-rich AKT1 substrate 1

Also known as: AKTS1_HUMAN, Lobe, MGC2865, PRAS40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96B36
Gene: AKT1S1
Ensembl: ENSG00000204673
Chromosome: 19
Canonical length: 256 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>Q96B36|AKT1S1
     1  MASGRPEELW EAVVGAAERF RARTGTELVL LTAAPPPPPR PGPCAYAAHG RGALAEAARR
    61  CLHDIALAHR AATAARPPAP PPAPQPPSPT PSPPRPTLAR EDNEEDEDEP TETETSGEQL
   121  GISDNGGLFV MDEDATLQDL PPFCESDPES TDDGSLSEET PAGPPTCSVP PASALPTQQY
   181  AKSLPVSVPV WGFKEKRTEA RSSDEENGPP SSPDLDRIAA SMRALVLREA EDTQVFGDLP
   241  RPRLNTSDFQ KLKRKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKT1S1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 113 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 113 nTPM
liver: 62 nTPM
esophagus: 51 nTPM
skin: 51 nTPM
adrenal gland: 51 nTPM
heart muscle: 44 nTPM

Single-cell type

respiratory ionocytes: 5.1 nCPM
syncytiotrophoblasts: 3 nCPM
thymic myoid cells: 2.7 nCPM
epicardial cells: 2.3 nCPM
late spermatids: 2 nCPM
parietal cells: 1.8 nCPM

Immune cell

neutrophil: 1.7 nTPM
non-classical monocyte: 1.6 nTPM
intermediate monocyte: 1.4 nTPM
plasmacytoid DC: 1.2 nTPM
classical monocyte: 1.1 nTPM
T-reg: 1 nTPM

Brain region

midbrain: 58 nTPM
medulla oblongata: 56 nTPM
pons: 56 nTPM
thalamus: 52 nTPM
white matter: 50 nTPM
basal ganglia: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.11
gnomAD missense Z: 0.64
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Proline-rich AKT1 substrate 1 protein
Proline-rich AKT1 substrate 1, N-terminal domain
Proline-rich AKT1 substrate 1
Proline-rich AKT1 substrate 1, N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKT1S1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKT1S1 as an antibody target. Whether an autoantibody or antibody against AKT1S1 could matter depends on whether native AKT1S1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKT1S1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKT1S1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...