Seroatlas · Human Serome Atlas

LAMTOR4

Ragulator complex protein LAMTOR4

Also known as: C7orf59, LTOR4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VGL1
Gene: LAMTOR4
Ensembl: ENSG00000188186
Chromosome: 7
Canonical length: 99 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and protein localization to lysosome. Located in lysosome. Part of FNIP-folliculin RagC/D GAP and Ragulator complex. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

99 residues, UniProt reviewed canonical sequence.

>Q0VGL1|LAMTOR4
     1  MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA CGFRLHRGMN
    61  VPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMTOR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 470 nTPM

Expression across tissuesHPA

Tissue

skin: 470 nTPM
choroid plexus: 284 nTPM
spleen: 247 nTPM
midbrain: 242 nTPM
spinal cord: 237 nTPM
amygdala: 218 nTPM

Single-cell type

colonocytes: 852 nCPM
hofbauer cells: 704 nCPM
neutrophils: 515 nCPM
gastric progenitor cells: 505 nCPM
enteric transient amplifying cells: 484 nCPM
suprabasal keratinocytes: 453 nCPM

Immune cell

neutrophil: 3,379 nTPM
eosinophil: 3,199 nTPM
basophil: 1,056 nTPM
total PBMC: 909 nTPM
classical monocyte: 864 nTPM
intermediate monocyte: 814 nTPM

Brain region

white matter: 112 nTPM
medulla oblongata: 110 nTPM
cerebellum: 107 nTPM
spinal cord: 102 nTPM
thalamus: 98 nTPM
basal ganglia: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.48
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ragulator complex protein LAMTOR4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAMTOR4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAMTOR4 as an antibody target. Whether an autoantibody or antibody against LAMTOR4 could matter depends on whether native LAMTOR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAMTOR4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LAMTOR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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