Seroatlas · Human Serome Atlas

SIK3

Serine/threonine-protein kinase SIK3

Also known as: FLJ12240, KIAA0999, L19, QSK, SIK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2K2
Gene: SIK3
Ensembl: ENSG00000160584
Chromosome: 11
Canonical length: 1321 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1321 residues, UniProt reviewed canonical sequence.

>Q9Y2K2|SIK3
     1  MAAAAASGAG GAAGAGTGGA GPAGRLLPPP APGSPAAPAA VSPAAGQPRP PAPASRGPMP
    61  ARIGYYEIDR TIGKGNFAVV KRATHLVTKA KVAIKIIDKT QLDEENLKKI FREVQIMKML
   121  CHPHIIRLYQ VMETERMIYL VTEYASGGEI FDHLVAHGRM AEKEARRKFK QIVTAVYFCH
   181  CRNIVHRDLK AENLLLDANL NIKIADFGFS NLFTPGQLLK TWCGSPPYAA PELFEGKEYD
   241  GPKVDIWSLG VVLYVLVCGA LPFDGSTLQN LRARVLSGKF RIPFFMSTEC EHLIRHMLVL
   301  DPNKRLSMEQ ICKHKWMKLG DADPNFDRLI AECQQLKEER QVDPLNEDVL LAMEDMGLDK
   361  EQTLQSLRSD AYDHYSAIYS LLCDRHKRHK TLRLGALPSM PRALAFQAPV NIQAEQAGTA
   421  MNISVPQVQL INPENQIVEP DGTLNLDSDE GEEPSPEALV RYLSMRRHTV GVADPRTEVM
   481  EDLQKLLPGF PGVNPQAPFL QVAPNVNFMH NLLPMQNLQP TGQLEYKEQS LLQPPTLQLL
   541  NGMGPLGRRA SDGGANIQLH AQQLLKRPRG PSPLVTMTPA VPAVTPVDEE SSDGEPDQEA
   601  VQSSTYKDSN TLHLPTERFS PVRRFSDGAA SIQAFKAHLE KMGNNSSIKQ LQQECEQLQK
   661  MYGGQIDERT LEKTQQQHML YQQEQHHQIL QQQIQDSICP PQPSPPLQAA CENQPALLTH
   721  QLQRLRIQPS SPPPNHPNNH LFRQPSNSPP PMSSAMIQPH GAASSSQFQG LPSRSAIFQQ
   781  QPENCSSPPN VALTCLGMQQ PAQSQQVTIQ VQEPVDMLSN MPGTAAGSSG RGISISPSAG
   841  QMQMQHRTNL MATLSYGHRP LSKQLSADSA EAHSLNVNRF SPANYDQAHL HPHLFSDQSR
   901  GSPSSYSPST GVGFSPTQAL KVPPLDQFPT FPPSAHQQPP HYTTSALQQA LLSPTPPDYT
   961  RHQQVPHILQ GLLSPRHSLT GHSDIRLPPT EFAQLIKRQQ QQRQQQQQQQ QQQEYQELFR
  1021  HMNQGDAGSL APSLGGQSMT ERQALSYQNA DSYHHHTSPQ HLLQIRAQEC VSQASSPTPP
  1081  HGYAHQPALM HSESMEEDCS CEGAKDGFQD SKSSSTLTKG CHDSPLLLST GGPGDPESLL
  1141  GTVSHAQELG IHPYGHQPTA AFSKNKVPSR EPVIGNCMDR SSPGQAVELP DHNGLGYPAR
  1201  PSVHEHHRPR ALQRHHTIQN SDDAYVQLDN LPGMSLVAGK ALSSARMSDA VLSQSSLMGS
  1261  QQFQDGENEE CGASLGGHEH PDLSDGSQHL NSSCYPSTCI TDILLSYKHP EVSFSMEQAG
  1321  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 24 nTPM
testis: 20 nTPM
skeletal muscle: 18 nTPM
retina: 18 nTPM
parathyroid gland: 17 nTPM
thyroid gland: 16 nTPM

Single-cell type

neutrophils: 3,412 nCPM
oligodendrocytes: 2,588 nCPM
endometrial luminal cells: 2,138 nCPM
innate lymphoid cells: 1,888 nCPM
endometrial ciliated cells: 1,838 nCPM
endometrial glandular cells: 1,768 nCPM

Immune cell

basophil: 1.8 nTPM
non-classical monocyte: 1.5 nTPM
naive B-cell: 1 nTPM
neutrophil: 0.9 nTPM
myeloid DC: 0.6 nTPM
NK-cell: 0.6 nTPM

Brain region

white matter: 138 nTPM
thalamus: 132 nTPM
basal ganglia: 131 nTPM
cerebral cortex: 122 nTPM
midbrain: 105 nTPM
pons: 104 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SIK3.

Disease | AllUniProt

Conditions SIK3 is implicated in, by any mechanism.

Spondyloepimetaphyseal dysplasia, Krakow type (SEMDK) MIM:618162

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 205 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spondyloepimetaphyseal dysplasia, Krakow type

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 2.83
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIK3 as an antibody target. Whether an autoantibody or antibody against SIK3 could matter depends on whether native SIK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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