Seroatlas · Human Serome Atlas

EIF4EBP1

Eukaryotic translation initiation factor 4E-binding protein 1

Also known as: 4E-BP1, 4EBP1_HUMAN, PHAS-I

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13541
Gene: EIF4EBP1
Ensembl: ENSG00000187840
Chromosome: 8
Canonical length: 118 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q13541|EIF4EBP1
     1  MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM
    61  ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4EBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 310 nTPM

Expression across tissuesHPA

Tissue

pancreas: 310 nTPM
salivary gland: 155 nTPM
skeletal muscle: 140 nTPM
esophagus: 124 nTPM
liver: 98 nTPM
adipose tissue: 90 nTPM

Single-cell type

esophageal suprabasal cells: 550 nCPM
esophageal apical cells: 504 nCPM
esophageal basal cells: 493 nCPM
pancreatic acinar cells: 436 nCPM
hofbauer cells: 299 nCPM
extravillous trophoblasts: 291 nCPM

Immune cell

classical monocyte: 417 nTPM
intermediate monocyte: 337 nTPM
myeloid DC: 336 nTPM
non-classical monocyte: 270 nTPM
eosinophil: 259 nTPM
total PBMC: 258 nTPM

Brain region

choroid plexus: 20 nTPM
white matter: 16 nTPM
thalamus: 15 nTPM
hypothalamus: 15 nTPM
medulla oblongata: 14 nTPM
spinal cord: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF4EBP1.

Disease | ImmuneIEDB

Conditions an epitope on EIF4EBP1 was assayed in.

prostate adenocarcinoma B and T cell
prostate cancer B and T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0.21
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF4EBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF4EBP1 as an antibody target. Whether an autoantibody or antibody against EIF4EBP1 could matter depends on whether native EIF4EBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF4EBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF4EBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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