YWHAZ

Protein identityUniProt · HPA

UniProt accession

P63104

Gene

YWHAZ

Ensembl

ENSG00000164924

Chromosome

8

Canonical length

245 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Transporters

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>P63104|YWHAZ
     1  MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR
    61  VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QAESKVFYLK
   121  MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE
   181  ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG
   241  EGGEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YWHAZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

839 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about YWHAZ.

Disease | AllUniProt

Conditions YWHAZ is implicated in, by any mechanism.

• Popov-Chang syndrome (POPCHAS) MIM:618428

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Popov-Chang syndrome
• Cardiofaciocutaneous spectrum disorder

Disease | ImmuneIEDB

Conditions an epitope on YWHAZ was assayed in.

• type 1 diabetes mellitus T cell

ReferencesPubMed · IEDB

Publications for YWHAZ from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.94

gnomAD missense Z

3.1

DepMap mean gene effect

-0.68

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• cellular response to glucose starvation
• ERK1 and ERK2 cascade
• establishment of Golgi localization
• Golgi reassembly
• intracellular protein localization
• lung development
• negative regulation of apoptotic process
• negative regulation of innate immune response
• negative regulation of protein localization to nucleus
• negative regulation of TORC1 signaling
• negative regulation of transcription by RNA polymerase II
• protein phosphorylation
• protein targeting
• regulation of ERK1 and ERK2 cascade
• regulation of protein stability
• regulation of synapse maturation
• respiratory system process
• signal transduction
• synaptic target recognition
• tube formation

Molecular functions

• cadherin binding
• DNA-binding transcription factor binding
• identical protein binding
• phosphoserine residue binding
• protein domain specific binding
• protein kinase binding
• protein phosphatase binding
• protein sequestering activity
• RNA binding
• transmembrane transporter binding
• ubiquitin protein ligase binding

Cellular components

• blood microparticle
• cytoplasm
• cytosol
• extracellular exosome
• extracellular space
• focal adhesion
• glutamatergic synapse
• hippocampal mossy fiber to CA3 synapse
• melanosome
• nucleoplasm
• nucleus
• vesicle

Protein domainsUniProt · Pfam · InterPro

• 14-3-3 protein
• 14-3-3 protein, conserved site
• 14-3-3 domain
• 14-3-3 domain superfamily
• 14-3-3 protein

KeywordsUniProt

• Acetylation
• Cytoplasm
• Host-virus interaction
• Intellectual disability
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of YWHAZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ABL1
• ADAM22
• AK5
• AKT1
• ARHGEF2
• BAX
• BCL2L11
• BRAF
• BSPRY
• CDK16
• FOXO4
• GAB2
• LDB1
• MADD
• MARK3
• MEFV
• MLF1
• NOXA1
• PDE1A
• PI4KB
• SAMSN1
• SLITRK1
• SMARCB1
• SSH1
• TBC1D22A
• TBC1D22B
• TLK2
• TP53
• TRIM25
• WEE1
• ZFP36L1
• DAPK2
• HAP1
• CHEK1
• MAP3K5
• FOXO1
• TNFAIP3
• AANAT
• USP8
• RBM7