Seroatlas · Human Serome Atlas

BRAT1

Integrator complex assembly factor BRAT1

Also known as: BAAT1, BRAT1_HUMAN, C7orf27, MGC22916

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PJG6
Gene
BRAT1
Ensembl
ENSG00000106009
Chromosome
7
Canonical length
821 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

821 residues, UniProt reviewed canonical sequence.

>Q6PJG6|BRAT1
     1  MDPECAQLLP ALCAVLVDPR QPVADDTCLE KLLDWFKTVT EGESSVVLLQ EHPCLVELLS
    61  HVLKVQDLSS GVLSFSLRLA GTFAAQENCF QYLQQGELLP GLFGEPGPLG RATWAVPTVR
   121  SGWIQGLRSL AQHPSALRFL ADHGAVDTIF SLQGDSSLFV ASAASQLLVH VLALSMRGGA
   181  EGQPCLPGGD WPACAQKIMD HVEESLCSAA TPKVTQALNV LTTTFGRCQS PWTEALWVRL
   241  SPRVACLLER DPIPAAHSFV DLLLCVARSP VFSSSDGSLW ETVARALSCL GPTHMGPLAL
   301  GILKLEHCPQ ALRTQAFQVL LQPLACVLKA TVQAPGPPGL LDGTADDATT VDTLLASKSS
   361  CAGLLCRTLA HLEELQPLPQ RPSPWPQASL LGATVTVLRL CDGSAAPASS VGGHLCGTLA
   421  GCVRVQRAAL DFLGTLSQGT GPQELVTQAL AVLLECLESP GSSPTVLKKA FQATLRWLLS
   481  SPKTPGCSDL GPLIPQFLRE LFPVLQKRLC HPCWEVRDSA LEFLTQLSRH WGGQADFRCA
   541  LLASEVPQLA LQLLQDPESY VRASAVTAMG QLSSQGLHAP TSPEHAEARQ SLFLELLHIL
   601  SVDSEGFPRR AVMQVFTEWL RDGHADAAQD TEQFVATVLQ AASRDLDWEV RAQGLELALV
   661  FLGQTLGPPR THCPYAVALP EVAPAQPLTE ALRALCHVGL FDFAFCALFD CDRPVAQKSC
   721  DLLLFLRDKI ASYSSLREAR GSPNTASAEA TLPRWRAGEQ AQPPGDQEPE AVLAMLRSLD
   781  LEGLRSTLAE SSDHVEKSPQ SLLQDMLATG GFLQGDEADC Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • adrenal gland: 32 nTPM
  • prostate: 26 nTPM
  • cervix: 24 nTPM
  • cerebellum: 23 nTPM
  • ovary: 23 nTPM

Single-cell type

  • hofbauer cells: 66 nCPM
  • undifferentiated spermatogonia: 61 nCPM
  • differentiating spermatogonia: 60 nCPM
  • epididymal basal cells: 40 nCPM
  • early primary spermatocytes: 38 nCPM
  • late primary spermatocytes: 34 nCPM

Immune cell

  • myeloid DC: 33 nTPM
  • classical monocyte: 31 nTPM
  • intermediate monocyte: 28 nTPM
  • non-classical monocyte: 27 nTPM
  • neutrophil: 26 nTPM
  • plasmacytoid DC: 23 nTPM

Brain region

  • medulla oblongata: 24 nTPM
  • midbrain: 19 nTPM
  • hypothalamus: 19 nTPM
  • thalamus: 19 nTPM
  • cerebral cortex: 18 nTPM
  • basal ganglia: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BRAT1.

Disease | AllUniProt

Conditions BRAT1 is implicated in, by any mechanism.

  • Rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL) MIM:614498
  • Neurodevelopmental disorder with cerebellar atrophy and with or without seizures (NEDCAS) MIM:618056

Disease | GeneticClinVar

116 pathogenic / likely-pathogenic of 1,371 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
-0.59
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRAT1 as an antibody target. Whether an autoantibody or antibody against BRAT1 could matter depends on whether native BRAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BRAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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