Seroatlas · Human Serome Atlas

LAMTOR3

Ragulator complex protein LAMTOR3

Also known as: LTOR3_HUMAN, MAP2K1IP1, MAPBP, MAPKSP1, MP1, Ragulator3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHA4
Gene
LAMTOR3
Ensembl
ENSG00000109270
Chromosome
4
Canonical length
124 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q9UHA4|LAMTOR3
     1  MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDNA PEHALRPGFL STFALATDQG
    61  SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT GLIVSLEKEL APLFEELRQV
   121  VEVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMTOR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 37 nTPM
  • kidney: 36 nTPM
  • parathyroid gland: 34 nTPM
  • thyroid gland: 32 nTPM
  • bone marrow: 31 nTPM
  • esophagus: 28 nTPM

Single-cell type

  • esophageal apical cells: 321 nCPM
  • neutrophils: 184 nCPM
  • esophageal suprabasal cells: 137 nCPM
  • oocytes: 120 nCPM
  • parietal cells: 115 nCPM
  • hofbauer cells: 111 nCPM

Immune cell

  • neutrophil: 59 nTPM
  • basophil: 44 nTPM
  • eosinophil: 39 nTPM
  • non-classical monocyte: 29 nTPM
  • intermediate monocyte: 27 nTPM
  • myeloid DC: 19 nTPM

Brain region

  • cerebellum: 21 nTPM
  • cerebral cortex: 21 nTPM
  • midbrain: 20 nTPM
  • hypothalamus: 19 nTPM
  • thalamus: 18 nTPM
  • pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.73
gnomAD missense Z
0.04
DepMap mean gene effect
-0.58
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ragulator complex protein LAMTOR3
  • Mitogen-activated protein kinase kinase 1 interacting

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAMTOR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAMTOR3 as an antibody target. Whether an autoantibody or antibody against LAMTOR3 could matter depends on whether native LAMTOR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAMTOR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LAMTOR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LAMTOR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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