Seroatlas · Human Serome Atlas

APOBEC3C

DNA dC->dU-editing enzyme APOBEC-3C

Also known as: ABC3C_HUMAN, APOBEC1L, ARDC2, ARDC4, ARP5, bK150C2.3, PBI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRW3
Gene: APOBEC3C
Ensembl: ENSG00000244509
Chromosome: 22
Canonical length: 190 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Intermediate filaments
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q9NRW3|APOBEC3C
     1  MNPQIRNPMK AMYPGTFYFQ FKNLWEANDR NETWLCFTVE GIKRRSVVSW KTGVFRNQVD
    61  SETHCHAERC FLSWFCDDIL SPNTKYQVTW YTSWSPCPDC AGEVAEFLAR HSNVNLTIFT
   121  ARLYYFQYPC YQEGLRSLSQ EGVAVEIMDY EDFKYCWENF VYNDNEPFKP WKGLKTNFRL
   181  LKRRLRESLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOBEC3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

tonsil: 63 nTPM
lymph node: 54 nTPM
fallopian tube: 53 nTPM
epididymis: 49 nTPM
adrenal gland: 36 nTPM
spleen: 34 nTPM

Single-cell type

microglia: 9.3 nCPM
erythrocyte progenitors: 6.5 nCPM
platelets: 5.7 nCPM
nk-cells: 5 nCPM
megakaryocyte-erythroid progenitors: 4.7 nCPM
oligodendrocyte progenitor cells: 3.9 nCPM

Immune cell

gdT-cell: 309 nTPM
eosinophil: 277 nTPM
memory CD8 T-cell: 276 nTPM
naive B-cell: 250 nTPM
non-classical monocyte: 248 nTPM
memory B-cell: 242 nTPM

Brain region

white matter: 11 nTPM
medulla oblongata: 7.9 nTPM
spinal cord: 6.5 nTPM
thalamus: 5.7 nTPM
pons: 5.3 nTPM
hypothalamus: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.03
gnomAD missense Z: -0.46
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APOBEC3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOBEC3C as an antibody target. Whether an autoantibody or antibody against APOBEC3C could matter depends on whether native APOBEC3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOBEC3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOBEC3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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