Seroatlas · Human Serome Atlas

KHDRBS2

KH domain-containing, RNA-binding, signal transduction-associated protein 2

Also known as: KHDR2_HUMAN, MGC26664, SLM-1, SLM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VWX1
Gene
KHDRBS2
Ensembl
ENSG00000112232
Chromosome
6
Canonical length
349 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homooligomer

OverviewNCBI Gene

Predicted to enable mRNA binding activity and poly(A) binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q5VWX1|KHDRBS2
     1  MEEEKYLPEL MAEKDSLDPS FVHASRLLAE EIEKFQGSDG KKEDEEKKYL DVISNKNIKL
    61  SERVLIPVKQ YPKFNFVGKL LGPRGNSLKR LQEETGAKMS ILGKGSMRDK AKEEELRKSG
   121  EAKYAHLSDE LHVLIEVFAP PGEAYSRMSH ALEEIKKFLV PDYNDEIRQE QLRELSYLNG
   181  SEDSGRGRGI RGRGIRIAPT APSRGRGGAI PPPPPPGRGV LTPRGSTVTR GALPVPPVAR
   241  GVPTPRARGA PTVPGYRAPP PPAHEAYEEY GYDDGYGGEY DDQTYETYDN SYATQTQSVP
   301  EYYDYGHGVS EDAYDSYAPE EWATTRSSLK APPQRSARGG YREHPYGRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KHDRBS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
6.4 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 6.4 nTPM
  • thyroid gland: 3.8 nTPM
  • hypothalamus: 3.7 nTPM
  • retina: 3.7 nTPM
  • cerebral cortex: 3.6 nTPM
  • lung: 2.1 nTPM

Single-cell type

  • retinal bipolar cells: 963 nCPM
  • alveolar cells type 1: 827 nCPM
  • brain excitatory neurons: 762 nCPM
  • brain inhibitory neurons: 718 nCPM
  • müller glia: 492 nCPM
  • lactotrophs: 477 nCPM

Immune cell

  • naive B-cell: 6.9 nTPM
  • memory B-cell: 5.9 nTPM
  • plasmacytoid DC: 1.9 nTPM
  • classical monocyte: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM
  • total PBMC: 0.3 nTPM

Brain region

  • cerebral cortex: 27 nTPM
  • white matter: 19 nTPM
  • basal ganglia: 15 nTPM
  • hypothalamus: 13 nTPM
  • hippocampal formation: 8.9 nTPM
  • amygdala: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.04
gnomAD missense Z
0.02
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KHDRBS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KHDRBS2 as an antibody target. Whether an autoantibody or antibody against KHDRBS2 could matter depends on whether native KHDRBS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KHDRBS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KHDRBS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KHDRBS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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