Seroatlas · Human Serome Atlas

KHDRBS3

KH domain-containing, RNA-binding, signal transduction-associated protein 3

Also known as: Etle, etoile, KHDR3_HUMAN, SALP, SLM-2, SLM2, T-STAR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75525
Gene
KHDRBS3
Ensembl
ENSG00000131773
Chromosome
8
Canonical length
346 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and spermatogenesis. Located in nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>O75525|KHDRBS3
     1  MEEKYLPELM AEKDSLDPSF THALRLVNQE IEKFQKGEGK DEEKYIDVVI NKNMKLGQKV
    61  LIPVKQFPKF NFVGKLLGPR GNSLKRLQEE TLTKMSILGK GSMRDKAKEE ELRKSGEAKY
   121  FHLNDDLHVL IEVFAPPAEA YARMGHALEE IKKFLIPDYN DEIRQAQLQE LTYLNGGSEN
   181  ADVPVVRGKP TLRTRGVPAP AITRGRGGVT ARPVGVVVPR GTPTPRGVLS TRGPVSRGRG
   241  LLTPRARGVP PTGYRPPPPP PTQETYGEYD YDDGYGTAYD EQSYDSYDNS YSTPAQSGAD
   301  YYDYGHGLSE ETYDSYGQEE WTNSRHKAPS ARTAKGVYRD QPYGRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KHDRBS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
147 nTPM

Expression across tissuesHPA

Tissue

  • testis: 147 nTPM
  • cerebral cortex: 50 nTPM
  • skeletal muscle: 31 nTPM
  • tongue: 29 nTPM
  • amygdala: 28 nTPM
  • hippocampal formation: 27 nTPM

Single-cell type

  • microglia: 874 nCPM
  • oligodendrocyte progenitor cells: 832 nCPM
  • schwann cells: 656 nCPM
  • late primary spermatocytes: 549 nCPM
  • retinal bipolar cells: 450 nCPM
  • early spermatids: 433 nCPM

Immune cell

  • eosinophil: 1.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 159 nTPM
  • white matter: 137 nTPM
  • basal ganglia: 98 nTPM
  • hippocampal formation: 93 nTPM
  • medulla oblongata: 65 nTPM
  • amygdala: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.44
gnomAD missense Z
1.32
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KHDRBS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KHDRBS3 as an antibody target. Whether an autoantibody or antibody against KHDRBS3 could matter depends on whether native KHDRBS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KHDRBS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KHDRBS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KHDRBS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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