Seroatlas · Human Serome Atlas

ERAP1

Endoplasmic reticulum aminopeptidase 1

Also known as: A-LAP, ARTS-1, ERAAP1, ERAP1_HUMAN, KIAA0525, PILS-AP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZ08
Gene
ERAP1
Ensembl
ENSG00000164307
Chromosome
5
Canonical length
941 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

941 residues, UniProt reviewed canonical sequence.

>Q9NZ08|ERAP1
     1  MVFLPLKWSL ATMSFLLSSL LALLTVSTPS WCQSTEASPK RSDGTPFPWN KIRLPEYVIP
    61  VHYDLLIHAN LTTLTFWGTT KVEITASQPT STIILHSHHL QISRATLRKG AGERLSEEPL
   121  QVLEHPRQEQ IALLAPEPLL VGLPYTVVIH YAGNLSETFH GFYKSTYRTK EGELRILAST
   181  QFEPTAARMA FPCFDEPAFK ASFSIKIRRE PRHLAISNMP LVKSVTVAEG LIEDHFDVTV
   241  KMSTYLVAFI ISDFESVSKI TKSGVKVSVY AVPDKINQAD YALDAAVTLL EFYEDYFSIP
   301  YPLPKQDLAA IPDFQSGAME NWGLTTYRES ALLFDAEKSS ASSKLGITMT VAHELAHQWF
   361  GNLVTMEWWN DLWLNEGFAK FMEFVSVSVT HPELKVGDYF FGKCFDAMEV DALNSSHPVS
   421  TPVENPAQIR EMFDDVSYDK GACILNMLRE YLSADAFKSG IVQYLQKHSY KNTKNEDLWD
   481  SMASICPTDG VKGMDGFCSR SQHSSSSSHW HQEGVDVKTM MNTWTLQKGF PLITITVRGR
   541  NVHMKQEHYM KGSDGAPDTG YLWHVPLTFI TSKSDMVHRF LLKTKTDVLI LPEEVEWIKF
   601  NVGMNGYYIV HYEDDGWDSL TGLLKGTHTA VSSNDRASLI NNAFQLVSIG KLSIEKALDL
   661  SLYLKHETEI MPVFQGLNEL IPMYKLMEKR DMNEVETQFK AFLIRLLRDL IDKQTWTDEG
   721  SVSERMLRSQ LLLLACVHNY QPCVQRAEGY FRKWKESNGN LSLPVDVTLA VFAVGAQSTE
   781  GWDFLYSKYQ FSLSSTEKSQ IEFALCRTQN KEKLQWLLDE SFKGDKIKTQ EFPQILTLIG
   841  RNPVGYPLAW QFLRKNWNKL VQKFELGSSS IAHMVMGTTN QFSTRTRLEE VKGFFSSLKE
   901  NGSQLRCVQQ TIETIEENIG WMDKNFDKIR VWLQSEKLER M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 60 nTPM
  • thymus: 59 nTPM
  • small intestine: 52 nTPM
  • adipose tissue: 48 nTPM
  • placenta: 44 nTPM
  • rectum: 41 nTPM

Single-cell type

  • epicardial cells: 1,558 nCPM
  • cardiomyocytes: 644 nCPM
  • adipocytes: 217 nCPM
  • endometrial glandular cells: 203 nCPM
  • fibro-adipogenic progenitors: 150 nCPM
  • myonuclei: 135 nCPM

Immune cell

  • basophil: 29 nTPM
  • NK-cell: 23 nTPM
  • gdT-cell: 23 nTPM
  • naive CD4 T-cell: 22 nTPM
  • non-classical monocyte: 21 nTPM
  • MAIT T-cell: 20 nTPM

Brain region

  • cerebral cortex: 36 nTPM
  • medulla oblongata: 35 nTPM
  • thalamus: 32 nTPM
  • white matter: 31 nTPM
  • midbrain: 29 nTPM
  • hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.53
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERAP1 as an antibody target. Whether an autoantibody or antibody against ERAP1 could matter depends on whether native ERAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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