Seroatlas · Human Serome Atlas

YTHDC1

YTH domain-containing protein 1

Also known as: KIAA1966, YT521, YT521-B, YTDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MU7
Gene
YTHDC1
Ensembl
ENSG00000083896
Chromosome
4
Canonical length
727 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables N6-methyladenosine-containing RNA reader activity and RNA binding activity. Involved in gene expression and regulation of gene expression. Located in nuclear speck and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

727 residues, UniProt reviewed canonical sequence.

>Q96MU7|YTHDC1
     1  MAADSREEKD GELNVLDDIL TEVPEQDDEL YNPESEQDKN EKKGSKRKSD RMESTDTKRQ
    61  KPSVHSRQLV SKPLSSSVSN NKRIVSTKGK SATEYKNEEY QRSERNKRLD ADRKIRLSSS
   121  ASREPYKNQP EKTCVRKRDP ERRAKSPTPD GSERIGLEVD RRASRSSQSS KEEVNSEEYG
   181  SDHETGSSGS SDEQGNNTEN EEEGVEEDVE EDEEVEEDAE EDEEVDEDGE EEEEEEEEEE
   241  EEEEEEEEEY EQDERDQKEE GNDYDTRSEA SDSGSESVSF TDGSVRSGSG TDGSDEKKKE
   301  RKRARGISPI VFDRSGSSAS ESYAGSEKKH EKLSSSVRAV RKDQTSKLKY VLQDARFFLI
   361  KSNNHENVSL AKAKGVWSTL PVNEKKLNLA FRSARSVILI FSVRESGKFQ GFARLSSESH
   421  HGGSPIHWVL PAGMSAKMLG GVFKIDWICR RELPFTKSAH LTNPWNEHKP VKIGRDGQEI
   481  ELECGTQLCL LFPPDESIDL YQVIHKMRHK RRMHSQPRSR GRPSRREPVR DVGRRRPEDY
   541  DIHNSRKKPR IDYPPEFHQR PGYLKDPRYQ EVDRRFSGVR RDVFLNGSYN DYVREFHNMG
   601  PPPPWQGMPP YPGMEQPPHH PYYQHHAPPP QAHPPYSGHH PVPHEARYRD KRVHDYDMRV
   661  DDFLRRTQAV VSGRRSRPRE RDRERERDRP RDNRRDRERD RGRDRERERE RLCDRDRDRG
   721  ERGRYRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YTHDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 110 nTPM
  • ovary: 66 nTPM
  • cerebellum: 57 nTPM
  • vagina: 49 nTPM
  • skin: 49 nTPM
  • cervix: 48 nTPM

Single-cell type

  • epididymal basal cells: 148 nCPM
  • distal convoluted tubule cells: 131 nCPM
  • loop of henle epithelial cells: 126 nCPM
  • oligodendrocytes: 121 nCPM
  • renal connecting tubule cells: 115 nCPM
  • proximal tubule cells: 105 nCPM

Immune cell

  • neutrophil: 106 nTPM
  • basophil: 70 nTPM
  • naive B-cell: 45 nTPM
  • eosinophil: 41 nTPM
  • plasmacytoid DC: 39 nTPM
  • memory B-cell: 36 nTPM

Brain region

  • white matter: 57 nTPM
  • cerebellum: 57 nTPM
  • basal ganglia: 45 nTPM
  • hypothalamus: 45 nTPM
  • medulla oblongata: 42 nTPM
  • spinal cord: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.09
gnomAD pLI
1
gnomAD missense Z
2.48
DepMap mean gene effect
-0.68
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YTHDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YTHDC1 as an antibody target. Whether an autoantibody or antibody against YTHDC1 could matter depends on whether native YTHDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YTHDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YTHDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/YTHDC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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