Seroatlas · Human Serome Atlas

EMSY

BRCA2-interacting transcriptional repressor EMSY

Also known as: C11orf30, EMSY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z589
Gene: EMSY
Ensembl: ENSG00000158636
Chromosome: 11
Canonical length: 1322 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in DNA repair; chromatin organization; and regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1322 residues, UniProt reviewed canonical sequence.

>Q7Z589|EMSY
     1  MPVVWPTLLD LSRDECKRIL RKLELEAYAG VISALRAQGD LTKEKKDLLG ELSKVLSIST
    61  ERHRAEVRRA VNDERLTTIA HNMSGPNSSS EWSIEGRRLV PLMPRLVPQT AFTVTANAVA
   121  NAAIQHNASL PVPAETGSKE VVCYSYTSTT STPTSTPVPS GSIATVKSPR PASPASNVVV
   181  LPSGSTVYVK SVSCSDEDEK PRKRRRTNSS SSSPVVLKEV PKAVVPVSKT ITVPVSGSPK
   241  MSNIMQSIAN SLPPHMSPVK ITFTKPSTQT TNTTTQKVII VTTSPSSTFV PNILSKSHNY
   301  AAVTKLVPTS VIASTTQKPP VVITASQSSL VSNSSSGSSS STPSPIPNTV AVTAVVSSTP
   361  SVVMSTVAQG VSTSAIKMAS TRLPSPKSLV SAPTQILAQF PKQHQQSPKQ QLYQVQQQTQ
   421  QQVAQPSPVS HQQQPQQSPL PPGIKPTIQI KQESGVKIIT QQVQPSKILP KPVTATLPTS
   481  SNSPIMVVSS NGAIMTTKLV TTPTGTQATY TRPTVSPSIG RMAATPGAAT YVKTTSGSII
   541  TVVPKSLATL GGKIISSNIV SGTTTKITTI PMTSKPNVIV VQKTTGKGTT IQGLPGKNVV
   601  TTLLNAGGEK TIQTVPTGAK PAILTATRPI TKMIVTQPKG IGSTVQPAAK IIPTKIVYGQ
   661  QGKTQVLIKP KPVTFQATVV SEQTRQLVTE TLQQASRVAE AGNSSIQEGK EEPQNYTDSS
   721  SSSTESSQSS QDSQPVVHVI ASRRQDWSEH EIAMETSPTI IYQDVSSESQ SATSTIKALL
   781  ELQQTTVKEK LESKPRQPTI DLSQMAVPIQ MTQEKRHSPE SPSIAVVESE LVAEYITTER
   841  TDEGTEVAFP LLVSHRSQPQ QPSQPQRTLL QHVAQSQTAT QTSVVVKSIP ASSPGAITHI
   901  MQQALSSHTA FTKHSEELGT EEGEVEEMDT LDPQTGLFYR SALTQSQSAK QQKLSQPPLE
   961  QTQLQVKTLQ CFQTKQKQTI HLQADQLQHK LPQMPQLSIR HQKLTPLQQE QAQPKPDVQH
  1021  TQHPMVAKDR QLPTLMAQPP QTVVQVLAVK TTQQLPKLQQ APNQPKIYVQ PQTPQSQMSL
  1081  PASSEKQTAS QVEQPIITQG SSVTKITFEG RQPPTVTKIT GGSSVPKLTS PVTSISPIQA
  1141  SEKTAVSDIL KMSLMEAQID TNVEHMIVDP PKKALATSML TGEAGSLPST HMVVAGMANS
  1201  TPQQQKCRES CSSPSTVGSS LTTRKIDPPA VPATGQFMRI QNVGQKKAEE SPAEIIIQAI
  1261  PQYAIPCHSS SNVVVEPSGL LELNNFTSQQ LDDEETAMEQ DIDSSTEDGT EPSPSQSSAE
  1321  RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMSY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

retina: 16 nTPM
bone marrow: 12 nTPM
thymus: 12 nTPM
tongue: 11 nTPM
placenta: 11 nTPM
cerebellum: 11 nTPM

Single-cell type

myonuclei: 135 nCPM
choroid plexus epithelial cells: 124 nCPM
somatotrophs: 117 nCPM
lactotrophs: 115 nCPM
distal convoluted tubule cells: 110 nCPM
ependymal cells: 108 nCPM

Immune cell

basophil: 12 nTPM
eosinophil: 7.5 nTPM
neutrophil: 7.3 nTPM
memory CD8 T-cell: 5.5 nTPM
naive B-cell: 5 nTPM
T-reg: 4.7 nTPM

Brain region

cerebellum: 43 nTPM
white matter: 36 nTPM
cerebral cortex: 29 nTPM
hypothalamus: 28 nTPM
basal ganglia: 27 nTPM
choroid plexus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

ENT domain
BRCA2-interacting transcriptional repressor EMSY
ENT domain-like superfamily
ENT domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMSY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMSY as an antibody target. Whether an autoantibody or antibody against EMSY could matter depends on whether native EMSY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMSY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EMSY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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