Seroatlas · Human Serome Atlas

SAP30

Histone deacetylase complex subunit SAP30

Also known as: SAP30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75446
Gene
SAP30
Ensembl
ENSG00000164105
Chromosome
4
Canonical length
220 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>O75446|SAP30
     1  MNGFTPDEMS RGGDAAAAVA AVVAAAAAAA SAGNGTGAGT GAEVPGAGAV SAAGPPGAAG
    61  PGPGQLCCLR EDGERCGRAA GNASFSKRIQ KSISQKKVKI ELDKSARHLY ICDYHKNLIQ
   121  SVRNRRKRKG SDDDGGDSPV QDIDTPEVDL YQLQVNTLRR YKRHFKLPTR PGLNKAQLVE
   181  IVGCHFRSIP VNEKDTLTYF IYSVKNDKNK SDLKVDSGVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAP30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 40 nTPM
  • colon: 24 nTPM
  • spinal cord: 24 nTPM
  • testis: 24 nTPM
  • bone marrow: 22 nTPM
  • urinary bladder: 21 nTPM

Single-cell type

  • monocytes: 174 nCPM
  • monocyte progenitors: 126 nCPM
  • macrophages: 101 nCPM
  • gastric progenitor cells: 95 nCPM
  • kupffer cells: 77 nCPM
  • schwann cells: 74 nCPM

Immune cell

  • classical monocyte: 1.3 nTPM
  • myeloid DC: 1 nTPM
  • intermediate monocyte: 0.7 nTPM
  • gdT-cell: 0.6 nTPM
  • neutrophil: 0.5 nTPM
  • T-reg: 0.5 nTPM

Brain region

  • white matter: 37 nTPM
  • medulla oblongata: 26 nTPM
  • basal ganglia: 26 nTPM
  • spinal cord: 25 nTPM
  • cerebellum: 24 nTPM
  • hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.31
gnomAD missense Z
0.89
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAP30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAP30 as an antibody target. Whether an autoantibody or antibody against SAP30 could matter depends on whether native SAP30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAP30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAP30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAP30. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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