SUV39H1
Histone-lysine N-methyltransferase SUV39H1
Also known as: KMT1A, SUV39H, SUV91_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O43463
- Gene
- SUV39H1
- Ensembl
- ENSG00000101945
- Chromosome
- X
- Canonical length
- 412 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Canonical amino-acid sequenceUniProt
412 residues, UniProt reviewed canonical sequence.
>O43463|SUV39H1
1 MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGISKRNL YDFEVEYLCD YKKIREQEYY
61 LVKWRGYPDS ESTWEPRQNL KCVRILKQFH KDLERELLRR HHRSKTPRHL DPSLANYLVQ
121 KAKQRRALRR WEQELNAKRS HLGRITVENE VDLDGPPRAF VYINEYRVGE GITLNQVAVG
181 CECQDCLWAP TGGCCPGASL HKFAYNDQGQ VRLRAGLPIY ECNSRCRCGY DCPNRVVQKG
241 IRYDLCIFRT DDGRGWGVRT LEKIRKNSFV MEYVGEIITS EEAERRGQIY DRQGATYLFD
301 LDYVEDVYTV DAAYYGNISH FVNHSCDPNL QVYNVFIDNL DERLPRIAFF ATRTIRAGEE
361 LTFDYNMQVD PVDMESTRMD SNFGLAGLPG SPKKRVRIEC KCGTESCRKY LFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SUV39H1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 13 nTPM
- epididymis: 12 nTPM
- thymus: 9 nTPM
- lymph node: 7 nTPM
- liver: 6.8 nTPM
- tonsil: 6.5 nTPM
Single-cell type
- extravillous trophoblasts: 40 nCPM
- adrenal medulla cells: 21 nCPM
- epididymal principal cells: 17 nCPM
- megakaryocyte progenitors: 14 nCPM
- migrating cytotrophoblasts: 14 nCPM
- monocyte progenitors: 13 nCPM
Immune cell
- T-reg: 11 nTPM
- NK-cell: 11 nTPM
- memory CD8 T-cell: 9.1 nTPM
- gdT-cell: 8.5 nTPM
- eosinophil: 6.8 nTPM
- naive CD4 T-cell: 6.8 nTPM
Brain region
- midbrain: 10 nTPM
- medulla oblongata: 8.9 nTPM
- hypothalamus: 8.7 nTPM
- cerebral cortex: 8.4 nTPM
- pons: 8.3 nTPM
- cerebellum: 8.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.22
- gnomAD pLI
- 0.99
- gnomAD missense Z
- 3.49
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- blastocyst hatching
- cell differentiation
- cellular response to glucose starvation
- cellular response to hypoxia
- chromatin organization
- circadian rhythm
- determination of adult lifespan
- DNA damage response
- energy homeostasis
- epigenetic programming in the zygotic pronuclei
- heterochromatin formation
- heterochromatin organization
- methylation
- negative regulation of cell cycle
- negative regulation of DNA-templated transcription
- negative regulation of transcription by RNA polymerase II
- rDNA heterochromatin formation
- regulation of bone mineralization
- regulation of cellular senescence
- regulation of DNA repair
- regulation of multicellular organism growth
- regulation of transcription by glucose
- rRNA processing
Molecular functions
- chromatin binding
- histone H3 methyltransferase activity
- histone H3K9 methyltransferase activity
- histone H3K9 trimethyltransferase activity
- histone H3K9me2 methyltransferase activity
- histone methyltransferase activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- S-adenosylmethionine-dependent methyltransferase activity
- transcription cis-regulatory region binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Chromo/chromo shadow domain
- SET domain
- Post-SET domain
- Pre-SET domain
- Histone-lysine N-methyltransferase SUV39H1/2-like
- Chromo-like domain superfamily
- Chromo domain, conserved site
- Chromo domain
- SET domain superfamily
- Histone-lysine N-methyltransferase, H3 Lys-9 specific
- Chromo (CHRromatin Organisation MOdifier) domain
- SET domain
- Pre-SET motif
KeywordsUniProt
- Acetylation
- Biological rhythms
- Cell cycle
- Cell membrane
- Centromere
- Chromatin regulator
- Chromosome
- Cytoplasmic vesicle
- Differentiation
- Host-virus interaction
- Isopeptide bond
- Membrane
- Metal-binding
- Methyltransferase
- Nucleus
- Phosphoprotein
- Repressor
- rRNA processing
- S-adenosyl-L-methionine
- Transcription
- Transcription regulation
- Transferase
- Ubl conjugation
- Zinc
InteractionsUniProt · HPA
Protein binding partners of SUV39H1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SUV39H1 as an antibody target. Whether an autoantibody or antibody against SUV39H1 could matter depends on whether native SUV39H1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SUV39H1 is annotated at the cell surface, where native SUV39H1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SUV39H1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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