Seroatlas · Human Serome Atlas

PWWP2B

PWWP domain-containing protein 2B

Also known as: bA432J24.1, FLJ46823, PWP2B_HUMAN, PWWP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NUJ5
Gene
PWWP2B
Ensembl
ENSG00000171813
Chromosome
10
Canonical length
590 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables NuRD complex binding activity. Predicted to be involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of cold-induced thermogenesis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>Q6NUJ5|PWWP2B
     1  MEPRAGCRLP VRVEQVVNGA LVVTVSCGER SFAGILLDCT KKSGLFGLPP LAPLPQVDES
    61  PVNDSHGRAP EEGDAEVMQL GSSSPPPARG VQPPETTRPE PPPPLVPPLP AGSLPPYPPY
   121  FEGAPFPHPL WLRDTYKLWV PQPPPRTIKR TRRRLSRNRD PGRLILSTIR LRPRQVLCEK
   181  CKSTLSPPEA SPGPPAAPRA RRRLGSGPDR ELRKPEEPEN GEPTAAATAR RSKRERREED
   241  RAPAEQVPRS PVIKISYSTP QGKGEVVKIP SRVHGSLEPF RPQQAPQDDG SQDPEVLDRE
   301  SRDRPSCAPS ASIPKLKLTR PVPAGADLPP PKIRLKPHRL GDSEHEPVYR AELVGELNGY
   361  LRDSSPAPCA DGPAGGLADL SSGSSGEDDD FKSCPQGPQG REGLAFLVSC PEGRADCASE
   421  SACSSDSLDE ARSSGSEGTP ADTGDLSPGH GASAPSVSRE ARQTVPPLTV RLHTQSVSEC
   481  ITEDGRTVAV GDIVWGKIHG FPWWPARVLD ISLGQKEDGE PSWREAKVSW FGSPTTSFLS
   541  ISKLSPFSEF FKLRFNRKKK GMYRKAITEA ANAARHVAPE IRELLTQFET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PWWP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 37 nTPM
  • adrenal gland: 30 nTPM
  • spleen: 26 nTPM
  • basal ganglia: 23 nTPM
  • esophagus: 22 nTPM
  • skeletal muscle: 22 nTPM

Single-cell type

  • esophageal apical cells: 124 nCPM
  • late spermatids: 117 nCPM
  • syncytiotrophoblasts: 67 nCPM
  • respiratory ciliated cells: 61 nCPM
  • extravillous trophoblasts: 61 nCPM
  • migrating cytotrophoblasts: 57 nCPM

Immune cell

  • NK-cell: 5.4 nTPM
  • non-classical monocyte: 5.3 nTPM
  • intermediate monocyte: 3.5 nTPM
  • naive B-cell: 3.3 nTPM
  • eosinophil: 2.6 nTPM
  • classical monocyte: 1.6 nTPM

Brain region

  • basal ganglia: 37 nTPM
  • cerebral cortex: 28 nTPM
  • hippocampal formation: 28 nTPM
  • amygdala: 25 nTPM
  • choroid plexus: 25 nTPM
  • medulla oblongata: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.84
gnomAD missense Z
1.42
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PWWP2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PWWP2B as an antibody target. Whether an autoantibody or antibody against PWWP2B could matter depends on whether native PWWP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PWWP2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PWWP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PWWP2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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