Seroatlas · Human Serome Atlas

CDK2AP1

Cyclin-dependent kinase 2-associated protein 1

Also known as: CDKA1_HUMAN, doc-1, DOC1, DORC1, p12DOC-1, ST19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14519
Gene
CDK2AP1
Ensembl
ENSG00000111328
Chromosome
12
Canonical length
115 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>O14519|CDK2AP1
     1  MSYKPNLAAH MPAAALNAAG SVHSPSTSMA TSSQYRQLLS DYGPPSLGYT QGTGNSQVPQ
    61  SKYAELLAII EELGKEIRPT YAGSKSAMER LKRGIIHARG LVRECLAETE RNARS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK2AP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
431 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 431 nTPM
  • midbrain: 336 nTPM
  • hippocampal formation: 251 nTPM
  • amygdala: 243 nTPM
  • basal ganglia: 238 nTPM
  • hypothalamus: 229 nTPM

Single-cell type

  • megakaryocytes: 569 nCPM
  • platelets: 308 nCPM
  • late spermatids: 264 nCPM
  • breast myoepithelial cells: 208 nCPM
  • müller glia: 207 nCPM
  • breast secretory cells: 191 nCPM

Immune cell

  • non-classical monocyte: 177 nTPM
  • intermediate monocyte: 153 nTPM
  • myeloid DC: 53 nTPM
  • classical monocyte: 45 nTPM
  • total PBMC: 30 nTPM
  • eosinophil: 21 nTPM

Brain region

  • medulla oblongata: 262 nTPM
  • spinal cord: 255 nTPM
  • white matter: 237 nTPM
  • hypothalamus: 212 nTPM
  • cerebellum: 204 nTPM
  • thalamus: 188 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0.45
gnomAD missense Z
1.42
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK2AP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK2AP1 as an antibody target. Whether an autoantibody or antibody against CDK2AP1 could matter depends on whether native CDK2AP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK2AP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK2AP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK2AP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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