Seroatlas · Human Serome Atlas

EPOP

Elongin BC and Polycomb repressive complex 2-associated protein

Also known as: C17orf96, EPOP_HUMAN, LOC100170841, PRR28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NHQ4
Gene
EPOP
Ensembl
ENSG00000273604
Chromosome
17
Canonical length
379 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Predicted to be involved in neuron fate commitment; regulation of transcription by RNA polymerase II; and stem cell differentiation. Predicted to be located in chromosome and nucleus. Predicted to be part of ESC/E(Z) complex and elongin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

379 residues, UniProt reviewed canonical sequence.

>A6NHQ4|EPOP
     1  METLCPAPRL AVPASPRGSP CSPTPRKPCR GTQEFSPLCL RALAFCALAK PRASSLGPGP
    61  GELAARSPVL RGPQAPLRPG GWAPDGLKHL WAPTGRPGVP NTAAGEDADV AACPRRGEEE
   121  EGGGGFPHFG VRSCAPPGRC PAPPHPREST TSFASAPPRP APGLEPQRGP AASPPQEPSS
   181  RPPSPPAGLS TEPAGPGTAP RPFLPGQPAE VDGNPPPAAP EAPAASPSTA SPAPAAPGDL
   241  RQEHFDRLIR RSKLWCYAKG FALDTPSLRR GPERPPAKGP ARGAAKKRRL PAPPPRTAQP
   301  RRPAPTLPTT STFSLLNCFP CPPALVVGED GDLKPASSLR LQGDSKPPPA HPLWRWQMGG
   361  PAVPEPPGLK FWGINMDES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPOP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 14 nTPM
  • testis: 11 nTPM
  • amygdala: 5.8 nTPM
  • parathyroid gland: 4.5 nTPM
  • liver: 4.2 nTPM
  • basal ganglia: 3.9 nTPM

Single-cell type

  • brain inhibitory neurons: 2 nCPM
  • brain excitatory neurons: 1.9 nCPM
  • oligodendrocyte progenitor cells: 1.6 nCPM
  • bergmann glia: 1.4 nCPM
  • astrocytes: 1 nCPM
  • renal collecting duct intercalated cells: 0.9 nCPM

Immune cell

  • MAIT T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 22 nTPM
  • basal ganglia: 16 nTPM
  • white matter: 12 nTPM
  • amygdala: 6.7 nTPM
  • hippocampal formation: 4.6 nTPM
  • midbrain: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0.28
DepMap mean gene effect
-0.54
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPOP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPOP as an antibody target. Whether an autoantibody or antibody against EPOP could matter depends on whether native EPOP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPOP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EPOP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EPOP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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