Seroatlas · Human Serome Atlas

PWWP2A

PWWP domain-containing protein 2A

Also known as: KIAA1935, PWP2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96N64
Gene
PWWP2A
Ensembl
ENSG00000170234
Chromosome
5
Canonical length
755 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Focal adhesion sites

OverviewNCBI Gene

Enables NuRD complex binding activity; chromatin binding activity; and methylated histone binding activity. Involved in chromatin remodeling. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

755 residues, UniProt reviewed canonical sequence.

>Q96N64|PWWP2A
     1  MAAVAAEAAA TAASPGEGGA GEAEPEMEPI PGSEAGTDPL PVTATEASVP DGETDGQQSA
    61  PQADEPPLPP PPPPPGELAR SPEAVGPELE AEEKLSVRVA ESAAAAPQGG PELPPSPASP
   121  PEQPPAPEER EEPPLPQPVA PALVPPAGGD STVSQLIPGS EVRVTLDHII EDALVVSFRF
   181  GEKLFSGVLM DLSKRFGPHG IPVTVFPKRE YKDKPEAMPL QSNTFQEGTE VKCEANGAVP
   241  DDPSPVPHPE LSLAESLWTS KPPPLFHEGA PYPPPLFIRD TYNQSIPQPP PRKIKRPKRK
   301  MYREEPTSIM NAIKLRPRQV LCDKCKNSVV AEKKEIRKGS SATDSSKYED KKRRNESVTT
   361  VNKKLKTDHK VDGKNQNESQ KRNAVVKVSN IAHSRGRVVK VSAQANTSKA QLSTKKVLQS
   421  KNMDHAKARE VLKIAKEKAQ KKQNETSTSK NAHSKVHFTR RYQNPSSGSL PPRVRLKPQR
   481  YRNEENDSSL KTGLEKMRSG KMAPKPQSRC TSTRSAGEAP SENQSPSKGP EEASSEVQDT
   541  NEVHVPGDQD EPQTLGKKGS KNNISVYMTL NQKKSDSSSA SVCSIDSTDD LKSSNSECSS
   601  SESFDFPPGS MHAPSTSSTS SSSKEEKKLS NSLKMKVFSK NVSKCVTPDG RTICVGDIVW
   661  AKIYGFPWWP ARILTITVSR KDNGLLVRQE ARISWFGSPT TSFLALSQLS PFLENFQSRF
   721  NKKRKGLYRK AITEAAKAAK QLTPEVRALL TQFET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PWWP2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 17 nTPM
  • retina: 13 nTPM
  • thymus: 12 nTPM
  • skin: 11 nTPM
  • rectum: 10 nTPM
  • colon: 9.8 nTPM

Single-cell type

  • oligodendrocytes: 196 nCPM
  • retinal bipolar cells: 164 nCPM
  • choroid plexus epithelial cells: 155 nCPM
  • bergmann glia: 153 nCPM
  • myonuclei: 137 nCPM
  • gonadotrophs: 133 nCPM

Immune cell

  • memory B-cell: 3.3 nTPM
  • basophil: 3.2 nTPM
  • neutrophil: 2.1 nTPM
  • classical monocyte: 2 nTPM
  • naive CD4 T-cell: 2 nTPM
  • naive B-cell: 1.6 nTPM

Brain region

  • white matter: 57 nTPM
  • cerebellum: 56 nTPM
  • basal ganglia: 39 nTPM
  • medulla oblongata: 35 nTPM
  • midbrain: 34 nTPM
  • pons: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.35
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PWWP2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PWWP2A as an antibody target. Whether an autoantibody or antibody against PWWP2A could matter depends on whether native PWWP2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PWWP2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PWWP2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PWWP2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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