Seroatlas · Human Serome Atlas

BRMS1

Breast cancer metastasis-suppressor 1

Also known as: BRMS1_HUMAN, DKFZP564A063

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCU9
Gene: BRMS1
Ensembl: ENSG00000174744
Chromosome: 11
Canonical length: 246 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Centrosome
Quaternary structure: Homohexamer

OverviewNCBI Gene

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q9HCU9|BRMS1
     1  MPVQPPSKDT EEMEAEGDSA AEMNGEEEES EEERSGSQTE SEEESSEMDD EDYERRRSEC
    61  VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE YTEPLGGLQR SLKIRIQVAG
   121  IYKGFCLDVI RNKYECELQG AKQHLESEKL LLYDTLQGEL QERIQRLEED RQSLDLSSEW
   181  WDDKLHARGS SRSWDSLPPS KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK
   241  RKSDGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRMS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 49 nTPM
skin: 40 nTPM
pancreas: 40 nTPM
kidney: 38 nTPM
spleen: 38 nTPM
skeletal muscle: 37 nTPM

Single-cell type

esophageal basal cells: 129 nCPM
oocytes: 124 nCPM
esophageal suprabasal cells: 94 nCPM
colonocytes: 93 nCPM
extravillous trophoblasts: 82 nCPM
syncytiotrophoblasts: 79 nCPM

Immune cell

neutrophil: 105 nTPM
eosinophil: 81 nTPM
T-reg: 80 nTPM
classical monocyte: 80 nTPM
memory B-cell: 80 nTPM
intermediate monocyte: 77 nTPM

Brain region

medulla oblongata: 18 nTPM
white matter: 18 nTPM
thalamus: 18 nTPM
cerebellum: 18 nTPM
midbrain: 18 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRMS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRMS1 as an antibody target. Whether an autoantibody or antibody against BRMS1 could matter depends on whether native BRMS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRMS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRMS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...