Seroatlas · Human Serome Atlas

ARID4A

AT-rich interactive domain-containing protein 4A

Also known as: ARI4A_HUMAN, RBBP1, RBP-1, RBP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P29374
Gene: ARID4A
Ensembl: ENSG00000032219
Chromosome: 14
Canonical length: 1257 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1257 residues, UniProt reviewed canonical sequence.

>P29374|ARID4A
     1  MKAADEPAYL TVGTDVSAKY RGAFCEAKIK TVKRLVKVKV LLKQDNTTQL VQDDQVKGPL
    61  RVGAIVETRT SDGSFQEAII SKLTDASWYT VVFDDGDERT LRRTSLCLKG ERHFAESETL
   121  DQLPLTNPEH FGTPVIAKKT NRGRRSSLPV TEDEKEEESS EEEDEDKRRL NDELLGKVVS
   181  VVSATERTEW YPALVISPSC NDDITVKKDQ CLVRSFIDSK FYSIARKDIK EVDILNLPES
   241  ELSTKPGLQK ASIFLKTRVV PDNWKMDISE ILESSSSDDE DGPAEENDEE KEKEAKKTEE
   301  EVPEEELDPE ERDNFLQQLY KFMEDRGTPI NKPPVLGYKD LNLFKLFRLV YHQGGCDNID
   361  SGAVWKQIYM DLGIPILNSA ASYNVKTAYR KYLYGFEEYC RSANIQFRTV HHHEPKVKEE
   421  KKDLEESMEE ALKLDQEMPL TEVKSEPEEN IDSNSESERE EIELKSPRGR RRIARDVNSI
   481  KKEIEEEKTE DKLKDNDTEN KDVDDDYETA EKKENELLLG RKNTPKQKEK KIKKQEDSDK
   541  DSDEEEEKSQ EREETESKCD SEGEEDEEDM EPCLTGTKVK VKYGRGKTQK IYEASIKSTE
   601  IDDGEVLYLV HYYGWNVRYD EWVKADRIIW PLDKGGPKKK QKKKAKNKED SEKDEKRDEE
   661  RQKSKRGRPP LKSTLSSNMP YGLSKTANSE GKSDSCSSDS ETEDALEKNL INEELSLKDE
   721  LEKNENLNDD KLDEENPKIS AHILKENDRT QMQPLETLKL EVGENEQIVQ IFGNKMEKTE
   781  EVKKEAEKSP KGKGRRSKTK DLSLEIIKIS SFGQNEAGSE PHIEAHSLEL SSLDNKNFSS
   841  ATEDEIDQCV KEKKLKRKIL GQSSPEKKIR IENGMEMTNT VSQERTSDCI GSEGMKNLNF
   901  EQHFERENEG MPSLIAESNQ CIQQLTSERF DSPAEETVNI PLKEDEDAMP LIGPETLVCH
   961  EVDLDDLDEK DKTSIEDVAV ESSESNSLVS IPPALPPVVQ HNFSVASPLT LSQDESRSVK
  1021  SESDITIEVD SIAEESQEGL CERESANGFE TNVASGTCSI IVQERESREK GQKRPSDGNS
  1081  GLMAKKQKRT PKRTSAAAKN EKNGTGQSSD SEDLPVLDNS SKCTPVKHLN VSKPQKLARS
  1141  PARISPHIKD GEKDKHREKH PNSSPRTYKW SFQLNELDNM NSTERISFLQ EKLQEIRKYY
  1201  MSLKSEVATI DRRRKRLKKK DREVSHAGAS MSSASSDTGM SPSSSSPPQN VLAVECR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARID4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 33 nTPM
liver: 18 nTPM
lymph node: 14 nTPM
thymus: 14 nTPM
cerebral cortex: 13 nTPM
spleen: 13 nTPM

Single-cell type

neutrophils: 421 nCPM
neutrophil progenitors: 309 nCPM
epididymal efferent duct absorptive cells: 181 nCPM
esophageal apical cells: 157 nCPM
other brain neurons: 148 nCPM
corticotrophs: 146 nCPM

Immune cell

neutrophil: 110 nTPM
basophil: 66 nTPM
eosinophil: 59 nTPM
naive B-cell: 43 nTPM
non-classical monocyte: 41 nTPM
memory B-cell: 32 nTPM

Brain region

cerebellum: 40 nTPM
hypothalamus: 35 nTPM
white matter: 31 nTPM
cerebral cortex: 29 nTPM
basal ganglia: 28 nTPM
choroid plexus: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARID4A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 163 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Multiple myeloma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 1.45
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Chromo/chromo shadow domain
ARID DNA-binding domain
Tudor domain
ARID4A/B, PWWP domain
Chromo-like domain superfamily
RNA binding activity-knot of a chromodomain
ARID DNA-binding domain superfamily
AT-rich Interactive Domain/SWI1 Chromatin Remodeling
ARID/BRIGHT DNA binding domain
RBB1NT (NUC162) domain
RNA binding activity-knot of a chromodomain
ARID4A, first Tudor domain
ARID4A, chromo barrel domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARID4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARID4A as an antibody target. Whether an autoantibody or antibody against ARID4A could matter depends on whether native ARID4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARID4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARID4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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