Seroatlas · Human Serome Atlas

ARID4B

AT-rich interactive domain-containing protein 4B

Also known as: ARI4B_HUMAN, BCAA, BRCAA1, RBP1L1, SAP180

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4LE39
Gene: ARID4B
Ensembl: ENSG00000054267
Chromosome: 1
Canonical length: 1312 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1312 residues, UniProt reviewed canonical sequence.

>Q4LE39|ARID4B
     1  MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE VQDDHIKGPL
    61  KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT LRRSSLCLKG ERHFAESETL
   121  DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP EEESSSSSSD EDEDDRKQID ELLGKVVCVD
   181  YISLDKKKAL WFPALVVCPD CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK
   241  PDAVLKQAFE QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE
   301  EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL GGFDNIESGA
   361  VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA NIEFQMALPE KVVNKQCKEC
   421  ENVKEIKVKE ENETEIKEIK MEEERNIIPR EEKPIEDEIE RKENIKPSLG SKKNLLESIP
   481  THSDQEKEVN IKKPEDNENL DDKDDDTTRV DESLNIKVEA EEEKAKSGDE TNKEEDEDDE
   541  EAEEEEEEEE EEEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG
   601  EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD KDEKYSPKNC
   661  KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI TSILNGLQAS ESSAEDSEQE
   721  DERGAQDMDN NGKEESKIDH LTNNRNDLIS KEEQNSSSLL EENKVHADLV ISKPVSKSPE
   781  RLRKDIEVLS EDTDYEEDEV TKKRKDVKKD TTDKSSKPQI KRGKRRYCNT EECLKTGSPG
   841  KKEEKAKNKE SLCMENSSNS SSDEDEEETK AKMTPTKKYN GLEEKRKSLR TTGFYSGFSE
   901  VAEKRIKLLN NSDERLQNSR AKDRKDVWSS IQGQWPKKTL KELFSDSDTE AAASPPHPAP
   961  EEGVAEESLQ TVAEEESCSP SVELEKPPPV NVDSKPIEEK TVEVNDRKAE FPSSGSNSVL
  1021  NTPPTTPESP SSVTVTEGSR QQSSVTVSEP LAPNQEEVRS IKSETDSTIE VDSVAGELQD
  1081  LQSEGNSSPA GFDASVSSSS SNQPEPEHPE KACTGQKRVK DAQGGGSSSK KQKRSHKATV
  1141  VNNKKKGKGT NSSDSEELSA GESITKSQPV KSVSTGMKSH STKSPARTQS PGKCGKNGDK
  1201  DPDLKEPSNR LPKVYKWSFQ MSDLENMTSA ERITILQEKL QEIRKHYLSL KSEVASIDRR
  1261  RKRLKKKERE SAATSSSSSS PSSSSITAAV MLTLAEPSMS SASQNGMSVE CR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARID4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 31 nTPM
thymus: 20 nTPM
lymph node: 20 nTPM
spleen: 17 nTPM
testis: 16 nTPM
thyroid gland: 16 nTPM

Single-cell type

neutrophils: 2,078 nCPM
late spermatids: 779 nCPM
neutrophil progenitors: 711 nCPM
innate lymphoid cells: 641 nCPM
t-cells: 596 nCPM
nk-cells: 579 nCPM

Immune cell

neutrophil: 73 nTPM
basophil: 62 nTPM
eosinophil: 41 nTPM
naive B-cell: 34 nTPM
NK-cell: 34 nTPM
memory B-cell: 32 nTPM

Brain region

cerebellum: 23 nTPM
white matter: 22 nTPM
basal ganglia: 19 nTPM
medulla oblongata: 18 nTPM
midbrain: 18 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.29
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

ARID DNA-binding domain
Tudor domain
ARID4A/B, PWWP domain
Chromo-like domain superfamily
RNA binding activity-knot of a chromodomain
ARID DNA-binding domain superfamily
AT-rich Interactive Domain/SWI1 Chromatin Remodeling
ARID/BRIGHT DNA binding domain
RBB1NT (NUC162) domain
RNA binding activity-knot of a chromodomain
ARID4B, ARID/BRIGHT domain
ARID4B, second Tudor domain
ARID4B, first Tudor domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARID4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARID4B as an antibody target. Whether an autoantibody or antibody against ARID4B could matter depends on whether native ARID4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARID4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies.

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