Seroatlas · Human Serome Atlas

GATAD1

GATA zinc finger domain-containing protein 1

Also known as: FLJ22489, GATD1_HUMAN, ODAG, RG083M05.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUU5
Gene
GATAD1
Ensembl
ENSG00000157259
Chromosome
7
Canonical length
269 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene contains a zinc finger at the N-terminus, and is thought to bind to a histone modification site that regulates gene expression. Mutations in this gene have been associated with autosomal recessive dilated cardiomyopathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

269 residues, UniProt reviewed canonical sequence.

>Q8WUU5|GATAD1
     1  MPLGLKPTCS VCKTTSSSMW KKGAQGEILC HHCTGRGGAG SGGAGSGAAG GTGGSGGGGF
    61  GAATFASTSA TPPQSNGGGG GKQSKQEIHR RSARLRNTKY KSAPAAEKKV STKGKGRRHI
   121  FKLKNPIKAP ESVSTIITAE SIFYKGVYYQ IGDVVSVIDE QDGKPYYAQI RGFIQDQYCE
   181  KSAALTWLIP TLSSPRDQFD PASYIIGPEE DLPRKMEYLE FVCHAPSEYF KSRSSPFPTV
   241  PTRPEKGYIW THVGPTPAIT IKESVANHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GATAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 24 nTPM
  • pancreas: 21 nTPM
  • thyroid gland: 19 nTPM
  • cervix: 18 nTPM
  • fallopian tube: 18 nTPM
  • prostate: 17 nTPM

Single-cell type

  • oligodendrocytes: 123 nCPM
  • myonuclei: 103 nCPM
  • bergmann glia: 76 nCPM
  • pituitary stem cells: 74 nCPM
  • thyrotrophs: 66 nCPM
  • oligodendrocyte progenitor cells: 66 nCPM

Immune cell

  • basophil: 2.8 nTPM
  • naive B-cell: 1.4 nTPM
  • plasmacytoid DC: 1.2 nTPM
  • classical monocyte: 1.1 nTPM
  • eosinophil: 1.1 nTPM
  • neutrophil: 1 nTPM

Brain region

  • white matter: 29 nTPM
  • basal ganglia: 23 nTPM
  • pons: 23 nTPM
  • cerebral cortex: 22 nTPM
  • medulla oblongata: 22 nTPM
  • thalamus: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GATAD1.

Disease | AllUniProt

Conditions GATAD1 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 310 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Dilated cardiomyopathy 2B

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.43
gnomAD missense Z
1.41
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GATAD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GATAD1 as an antibody target. Whether an autoantibody or antibody against GATAD1 could matter depends on whether native GATAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GATAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GATAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GATAD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...