Seroatlas · Human Serome Atlas

SAP130

Histone deacetylase complex subunit SAP130

Also known as: FLJ12761, SP130_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0E3
Gene
SAP130
Ensembl
ENSG00000136715
Chromosome
2
Canonical length
1048 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1048 residues, UniProt reviewed canonical sequence.

>Q9H0E3|SAP130
     1  MGPPRHPQAG EIEAGGAGGG RRLQVEMSSQ QFPRLGAPST GLSQAPSQIA NSGSAGLINP
    61  AATVNDESGR DSEVSAREHM SSSSSLQSRE EKQEPVVVRP YPQVQMLSTH HAVASATPVA
   121  VTAPPAHLTP AVPLSFSEGL MKPPPKPTMP SRPIAPAPPS TLSLPPKVPG QVTVTMESSI
   181  PQASAIPVAT ISGQQGHPSN LHHIMTTNVQ MSIIRSNAPG PPLHIGASHL PRGAAAAAVM
   241  SSSKVTTVLR PTSQLPNAAT AQPAVQHIIH QPIQSRPPVT TSNAIPPAVV ATVSATRAQS
   301  PVITTTAAHA TDSALSRPTL SIQHPPSAAI SIQRPAQSRD VTTRITLPSH PALGTPKQQL
   361  HTMAQKTIFS TGTPVAAATV APILATNTIP SATTAGSVSH TQAPTSTIVT MTVPSHSSHA
   421  TAVTTSNIPV AKVVPQQITH TSPRIQPDYP AERSSLIPIS GHRASPNPVA METRSDNRPS
   481  VPVQFQYFLP TYPPSAYPLA AHTYTPITSS VSTIRQYPVS AQAPNSAITA QTGVGVASTV
   541  HLNPMQLMTV DASHARHIQG IQPAPISTQG IQPAPIGTPG IQPAPLGTQG IHSATPINTQ
   601  GLQPAPMGTQ QPQPEGKTSA VVLADGATIV ANPISNPFSA APAATTVVQT HSQSASTNAP
   661  AQGSSPRPSI LRKKPATDGA KPKSEIHVSM ATPVTVSMET VSNQNNDQPT IAVPPTAQQP
   721  PPTIPTMIAA ASPPSQPAVA LSTIPGAVPI TPPITTIAAA PPPSVTVGGS LSSVLGPPVP
   781  EIKVKEEVEP MDIMRPVSAV PPLATNTVSP SLALLANNLS MPTSDLPPGA SPRKKPRKQQ
   841  HVISTEEGDM METNSTDDEK STAKSLLVKA EKRKSPPKEY IDEEGVRYVP VRPRPPITLL
   901  RHYRNPWKAA YHHFQRYSDV RVKEEKKAML QEIANQKGVS CRAQGWKVHL CAAQLLQLTN
   961  LEHDVYERLT NLQEGIIPKK KAATDDDLHR INELIQGNMQ RCKLVMDQIS EARDSMLKVL
  1021  DHKDRVLKLL NKNGTVKKVS KLKRKEKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAP130 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • testis: 44 nTPM
  • bone marrow: 21 nTPM
  • pituitary gland: 14 nTPM
  • thymus: 14 nTPM
  • blood vessel: 13 nTPM
  • skin: 12 nTPM

Single-cell type

  • somatotrophs: 190 nCPM
  • sertoli cells: 136 nCPM
  • neutrophils: 125 nCPM
  • neutrophil progenitors: 89 nCPM
  • myonuclei: 85 nCPM
  • lactotrophs: 82 nCPM

Immune cell

  • neutrophil: 14 nTPM
  • non-classical monocyte: 8.7 nTPM
  • plasmacytoid DC: 6.2 nTPM
  • gdT-cell: 5.3 nTPM
  • naive B-cell: 5 nTPM
  • eosinophil: 4.6 nTPM

Brain region

  • hypothalamus: 32 nTPM
  • cerebral cortex: 30 nTPM
  • basal ganglia: 27 nTPM
  • cerebellum: 27 nTPM
  • midbrain: 27 nTPM
  • white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
3.25
DepMap mean gene effect
-0.45
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Histone deacetylase complex subunit SAP130
  • Histone deacetylase complex subunit SAP130, C-terminal domain
  • Histone deacetylase complex subunit SAP130 C-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAP130 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAP130 as an antibody target. Whether an autoantibody or antibody against SAP130 could matter depends on whether native SAP130 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAP130 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAP130 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAP130. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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