Seroatlas · Human Serome Atlas

BRMS1L

Breast cancer metastasis-suppressor 1-like protein

Also known as: BRM1L_HUMAN, BRMS1, FLJ39177, MGC11296

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5PSV4
Gene: BRMS1L
Ensembl: ENSG00000100916
Chromosome: 14
Canonical length: 323 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q5PSV4|BRMS1L
     1  MPVHSRGDKK ETNHHDEMEV DYAENEGSSS EDEDTESSSV SEDGDSSEMD DEDCERRRME
    61  CLDEMSNLEK QFTDLKDQLY KERLSQVDAK LQEVIAGKAP EYLEPLATLQ ENMQIRTKVA
   121  GIYRELCLES VKNKYECEIQ ASRQHCESEK LLLYDTVQSE LEEKIRRLEE DRHSIDITSE
   181  LWNDELQSRK KRKDPFSPDK KKPVVVSGPY IVYMLQDLDI LEDWTTIRKA MATLGPHRVK
   241  TEPPVKLEKH LHSARSEEGR LYYDGEWYIR GQTICIDKKD ECPTSAVITT INHDEVWFKR
   301  PDGSKSKLYI SQLQKGKYSI KHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRMS1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 14 nTPM
tongue: 13 nTPM
skeletal muscle: 13 nTPM
heart muscle: 11 nTPM
amygdala: 10 nTPM
adrenal gland: 9.5 nTPM

Single-cell type

salivary myoepithelial cells: 68 nCPM
thymic myoid cells: 53 nCPM
medullary thymic epithelial cells: 48 nCPM
vascular smooth muscle cells: 46 nCPM
lactotrophs: 43 nCPM
myonuclei: 41 nCPM

Immune cell

naive CD4 T-cell: 1.4 nTPM
non-classical monocyte: 1.4 nTPM
T-reg: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM
intermediate monocyte: 1.2 nTPM
naive CD8 T-cell: 1.2 nTPM

Brain region

white matter: 16 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 15 nTPM
midbrain: 13 nTPM
thalamus: 13 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.06
gnomAD missense Z: 2.15
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

histone deacetylase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRMS1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRMS1L as an antibody target. Whether an autoantibody or antibody against BRMS1L could matter depends on whether native BRMS1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRMS1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRMS1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...