Seroatlas · Human Serome Atlas

HDAC2

Histone deacetylase 2

Also known as: HDAC2_HUMAN, KDAC2, RPD3, YAF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92769
Gene
HDAC2
Ensembl
ENSG00000196591
Chromosome
6
Canonical length
488 aa
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q92769|HDAC2
     1  MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA
    61  TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA
   121  GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH
   181  GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ
   241  IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG
   301  GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM
   361  EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE
   421  FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT
   481  KSEQLSNP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDAC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • testis: 72 nTPM
  • thymus: 64 nTPM
  • bone marrow: 60 nTPM
  • urinary bladder: 59 nTPM
  • ovary: 56 nTPM
  • endometrium: 54 nTPM

Single-cell type

  • syncytiotrophoblasts: 271 nCPM
  • early primary spermatocytes: 255 nCPM
  • gastric progenitor cells: 224 nCPM
  • undifferentiated spermatogonia: 213 nCPM
  • migrating cytotrophoblasts: 210 nCPM
  • basal keratinocytes: 202 nCPM

Immune cell

  • myeloid DC: 51 nTPM
  • non-classical monocyte: 50 nTPM
  • plasmacytoid DC: 44 nTPM
  • basophil: 44 nTPM
  • eosinophil: 42 nTPM
  • naive CD4 T-cell: 42 nTPM

Brain region

  • white matter: 71 nTPM
  • hypothalamus: 67 nTPM
  • cerebellum: 63 nTPM
  • medulla oblongata: 61 nTPM
  • basal ganglia: 60 nTPM
  • pons: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HDAC2.

Disease | ImmuneIEDB

Conditions an epitope on HDAC2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.1
gnomAD pLI
1
gnomAD missense Z
4.05
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HDAC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDAC2 as an antibody target. Whether an autoantibody or antibody against HDAC2 could matter depends on whether native HDAC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDAC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDAC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HDAC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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