Seroatlas · Human Serome Atlas

PHF19

PHD finger protein 19

Also known as: DKFZP727G051, MTF2L1, PCL3, PHF19_HUMAN, TDRD19B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T6S3
Gene
PHF19
Ensembl
ENSG00000119403
Chromosome
9
Canonical length
580 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables methylated histone binding activity. Involved in negative regulation of gene expression, epigenetic. Located in ESC/E(Z) complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

580 residues, UniProt reviewed canonical sequence.

>Q5T6S3|PHF19
     1  MENRALDPGT RDSYGATSHL PNKGALAKVK NNFKDLMSKL TEGQYVLCRW TDGLYYLGKI
    61  KRVSSSKQSC LVTFEDNSKY WVLWKDIQHA GVPGEEPKCN ICLGKTSGPL NEILICGKCG
   121  LGYHQQCHIP IAGSADQPLL TPWFCRRCIF ALAVRKGGAL KKGAIARTLQ AVKMVLSYQP
   181  EELEWDSPHR TNQQQCYCYC GGPGEWYLRM LQCYRCRQWF HEACTQCLNE PMMFGDRFYL
   241  FFCSVCNQGP EYIERLPLRW VDVVHLALYN LGVQSKKKYF DFEEILAFVN HHWELLQLGK
   301  LTSTPVTDRG PHLLNALNSY KSRFLCGKEI KKKKCIFRLR IRVPPNPPGK LLPDKGLLPN
   361  ENSASSELRK RGKSKPGLLP HEFQQQKRRV YRRKRSKFLL EDAIPSSDFT SAWSTNHHLA
   421  SIFDFTLDEI QSLKSASSGQ TFFSDVDSTD AASTSGSAST SLSYDSRWTV GSRKRKLAAK
   481  AYMPLRAKRW AAELDGRCPS DSSAEGASVP ERPDEGIDSH TFESISEDDS SLSHLKSSIT
   541  NYFGAAGRLA CGEKYQVLAR RVTPEGKVQY LVEWEGTTPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 54 nTPM
  • tonsil: 43 nTPM
  • blood vessel: 39 nTPM
  • lymph node: 38 nTPM
  • thymus: 36 nTPM
  • pituitary gland: 29 nTPM

Single-cell type

  • monocyte progenitors: 82 nCPM
  • esophageal basal cells: 63 nCPM
  • monocytes: 61 nCPM
  • megakaryocyte progenitors: 53 nCPM
  • hofbauer cells: 46 nCPM
  • plasma cells: 42 nCPM

Immune cell

  • non-classical monocyte: 80 nTPM
  • intermediate monocyte: 58 nTPM
  • T-reg: 32 nTPM
  • myeloid DC: 14 nTPM
  • classical monocyte: 14 nTPM
  • memory CD4 T-cell: 12 nTPM

Brain region

  • white matter: 49 nTPM
  • medulla oblongata: 34 nTPM
  • basal ganglia: 34 nTPM
  • midbrain: 31 nTPM
  • cerebral cortex: 29 nTPM
  • thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
3.35
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHF19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHF19 as an antibody target. Whether an autoantibody or antibody against PHF19 could matter depends on whether native PHF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHF19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PHF19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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