Seroatlas · Human Serome Atlas

ING2

Inhibitor of growth protein 2

Also known as: ING1L, ING2_HUMAN, p33ING2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H160
Gene: ING2
Ensembl: ENSG00000168556
Chromosome: 4
Canonical length: 280 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q9H160|ING2
     1  MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL
    61  KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL
   121  HSQCFQDPAE SERASDKAKM DSSQPERSSR RPRRQRTSES RDLCHMANGI EDCDDQPPKE
   181  KKSKSAKKKK RSKAKQEREA SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF
   241  SCVSLTYKPK GKWYCPKCRG DNEKTMDKST EKTKKDRRSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ING2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

ovary: 33 nTPM
adrenal gland: 25 nTPM
testis: 21 nTPM
bone marrow: 20 nTPM
skeletal muscle: 15 nTPM
pancreas: 15 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 162 nCPM
granulosa cells: 159 nCPM
late primary spermatocytes: 155 nCPM
ovarian stromal cells: 146 nCPM
esophageal apical cells: 146 nCPM
extravillous trophoblasts: 128 nCPM

Immune cell

eosinophil: 20 nTPM
basophil: 15 nTPM
memory B-cell: 12 nTPM
naive CD4 T-cell: 8.9 nTPM
naive B-cell: 8.5 nTPM
non-classical monocyte: 8.5 nTPM

Brain region

hypothalamus: 20 nTPM
cerebral cortex: 15 nTPM
cerebellum: 13 nTPM
medulla oblongata: 13 nTPM
midbrain: 13 nTPM
pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.73
gnomAD missense Z: 1.74
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ING2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ING2 as an antibody target. Whether an autoantibody or antibody against ING2 could matter depends on whether native ING2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ING2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ING2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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