Seroatlas · Human Serome Atlas

ASF1B

Histone chaperone ASF1B

Also known as: ASF1B_HUMAN, FLJ10604

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVP2
Gene: ASF1B
Ensembl: ENSG00000105011
Chromosome: 19
Canonical length: 202 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q9NVP2|ASF1B
     1  MAKVSVLNVA VLENPSPFHS PFRFEISFEC SEALADDLEW KIIYVGSAES EEFDQILDSV
    61  LVGPVPAGRH MFVFQADAPN PSLIPETDAV GVTVVLITCT YHGQEFIRVG YYVNNEYLNP
   121  ELRENPPMKP DFSQLQRNIL ASNPRVTRFH INWDNNMDRL EAIETQDPSL GCGLPLNCTP
   181  IKGLGLPGCI PGLLPENSMD CI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASF1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

testis: 36 nTPM
thymus: 22 nTPM
tonsil: 14 nTPM
esophagus: 12 nTPM
lymph node: 12 nTPM
bone marrow: 11 nTPM

Single-cell type

early spermatids: 7 nCPM
late spermatids: 2.9 nCPM
renal collecting duct principal cells: 2.6 nCPM
papillary tip epithelial cells: 2 nCPM
late primary spermatocytes: 1.8 nCPM
microglia: 1.6 nCPM

Immune cell

neutrophil: 60 nTPM
non-classical monocyte: 8.6 nTPM
intermediate monocyte: 8 nTPM
classical monocyte: 6.2 nTPM
T-reg: 5.1 nTPM
total PBMC: 3.2 nTPM

Brain region

cerebellum: 1.1 nTPM
thalamus: 1.1 nTPM
medulla oblongata: 1 nTPM
white matter: 1 nTPM
basal ganglia: 0.9 nTPM
pons: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASF1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASF1B as an antibody target. Whether an autoantibody or antibody against ASF1B could matter depends on whether native ASF1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASF1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASF1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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