Seroatlas · Human Serome Atlas

ASF1A

Histone chaperone ASF1A

Also known as: ASF1A_HUMAN, CIA, DKFZP547E2110

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y294
Gene: ASF1A
Ensembl: ENSG00000111875
Chromosome: 6
Canonical length: 204 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q9Y294|ASF1A
     1  MAKVQVNNVV VLDNPSPFYN PFQFEITFEC IEDLSEDLEW KIIYVGSAES EEYDQVLDSV
    61  LVGPVPAGRH MFVFQADAPN PGLIPDADAV GVTVVLITCT YRGQEFIRVG YYVNNEYTET
   121  ELRENPPVKP DFSKLQRNIL ASNPRVTRFH INWEDNTEKL EDAESSNPNL QSLLSTDALP
   181  SASKGWSTSE NSLNVMLESH MDCM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASF1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

thymus: 23 nTPM
ovary: 19 nTPM
skeletal muscle: 16 nTPM
basal ganglia: 15 nTPM
tongue: 15 nTPM
lymph node: 15 nTPM

Single-cell type

oocytes: 345 nCPM
megakaryocytes: 93 nCPM
extravillous trophoblasts: 88 nCPM
cytotrophoblasts: 82 nCPM
migrating cytotrophoblasts: 72 nCPM
parietal cells: 67 nCPM

Immune cell

T-reg: 84 nTPM
naive CD4 T-cell: 69 nTPM
memory CD4 T-cell: 64 nTPM
naive CD8 T-cell: 57 nTPM
MAIT T-cell: 57 nTPM
memory CD8 T-cell: 52 nTPM

Brain region

white matter: 18 nTPM
cerebellum: 17 nTPM
spinal cord: 16 nTPM
basal ganglia: 16 nTPM
hypothalamus: 16 nTPM
medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.81
gnomAD missense Z: 2.39
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASF1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASF1A as an antibody target. Whether an autoantibody or antibody against ASF1A could matter depends on whether native ASF1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASF1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASF1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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