VAMP7
Vesicle-associated membrane protein 7
Also known as: SYBL1, TI-VAMP, VAMP-7, VAMP7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P51809
- Gene
- VAMP7
- Ensembl
- ENSG00000124333
- Chromosome
- X
- Canonical length
- 220 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Canonical amino-acid sequenceUniProt
220 residues, UniProt reviewed canonical sequence.
>P51809|VAMP7
1 MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY LFHYICQDRI
61 VYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY AMNSEFSSVL AAQLKHHSEN
121 KGLDKVMETQ AQVDELKGIM VRNIDLVAQR GERLELLIDK TENLVDSSVT FKTTSRNLAR
181 AMCMKNLKLT IIIIIVSIVF IYIIVSPLCG GFTWPSCVKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against VAMP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 45 nTPM
Expression across tissuesHPA
Tissue
- liver: 45 nTPM
- placenta: 38 nTPM
- kidney: 37 nTPM
- bone marrow: 35 nTPM
- parathyroid gland: 30 nTPM
- spinal cord: 30 nTPM
Single-cell type
- platelets: 114 nCPM
- syncytiotrophoblasts: 95 nCPM
- extravillous trophoblasts: 76 nCPM
- oocytes: 69 nCPM
- neutrophil progenitors: 65 nCPM
- cytotrophoblasts: 64 nCPM
Immune cell
- basophil: 87 nTPM
- eosinophil: 40 nTPM
- intermediate monocyte: 27 nTPM
- non-classical monocyte: 27 nTPM
- myeloid DC: 26 nTPM
- classical monocyte: 25 nTPM
Brain region
- white matter: 29 nTPM
- cerebellum: 28 nTPM
- pons: 27 nTPM
- hypothalamus: 27 nTPM
- medulla oblongata: 26 nTPM
- midbrain: 25 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about VAMP7.
Disease | ImmuneIEDB
Conditions an epitope on VAMP7 was assayed in.
- colonic benign neoplasm T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.86
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.66
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
OntologyGO
Biological processes
- calcium-ion regulated exocytosis
- endoplasmic reticulum to Golgi vesicle-mediated transport
- endosome to lysosome transport
- eosinophil degranulation
- exocytosis
- natural killer cell degranulation
- neutrophil degranulation
- phagocytosis, engulfment
- positive regulation of histamine secretion by mast cell
- protein transport
- vesicle fusion
- vesicle-mediated transport
Molecular functions
Cellular components
- azurophil granule membrane
- clathrin-coated endocytic vesicle membrane
- cytoplasm
- endoplasmic reticulum membrane
- extracellular exosome
- lamellipodium
- late endosome membrane
- lysosomal membrane
- membrane
- neuron projection
- phagocytic vesicle
- phagocytic vesicle membrane
- plasma membrane
- platelet alpha granule
- pseudopodium
- secretory granule
- secretory granule membrane
- SNARE complex
- synapse
- trans-Golgi network
- transport vesicle membrane
Protein domainsUniProt · Pfam · InterPro
- Synaptobrevin-like
- Longin domain
- Longin-like domain superfamily
- v-SNARE, coiled-coil homology domain
- Synaptobrevin
- Regulated-SNARE-like domain
- Synaptobrevin-like vesicular transport protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of VAMP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads VAMP7 as an antibody target. Whether an autoantibody or antibody against VAMP7 could matter depends on whether native VAMP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
VAMP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label VAMP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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