Seroatlas · Human Serome Atlas

ZFYVE27

Protrudin

Also known as: FLJ32919, SPG33, ZFY27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T4F4
Gene
ZFYVE27
Ensembl
ENSG00000155256
Chromosome
10
Canonical length
411 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q5T4F4|ZFYVE27
     1  MQTSEREGSG PELSPSVMPE APLESPPFPT KSPAFDLFNL VLSYKRLEIY LEPLKDAGDG
    61  VRYLLRWQMP LCSLLTCLGL NVLFLTLNEG AWYSVGALMI SVPALLGYLQ EVCRARLPDS
   121  ELMRRKYHSV RQEDLQRGRL SRPEAVAEVK SFLIQLEAFL SRLCCTCEAA YRVLHWENPV
   181  VSSQFYGALL GTVCMLYLLP LCWVLTLLNS TLFLGNVEFF RVVSEYRASL QQRMNPKQEE
   241  HAFESPPPPD VGGKDGLMDS TPALTPTEDL TPGSVEEAEE AEPDEEFKDA IEETHLVVLE
   301  DDEGAPCPAE DELALQDNGF LSKNEVLRSK VSRLTERLRK RYPTNNFGNC TGCSATFSVL
   361  KKRRSCSNCG NSFCSRCCSF KVPKSSMGAT APEAQRETVF VCASCNQTLS K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFYVE27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 36 nTPM
  • pituitary gland: 34 nTPM
  • liver: 30 nTPM
  • small intestine: 27 nTPM
  • retina: 26 nTPM
  • spleen: 26 nTPM

Single-cell type

  • cone photoreceptor cells: 87 nCPM
  • rod photoreceptor cells: 80 nCPM
  • retinal ganglion cells: 70 nCPM
  • tuft cells: 69 nCPM
  • enterocytes: 65 nCPM
  • epididymal principal cells: 56 nCPM

Immune cell

  • gdT-cell: 9.6 nTPM
  • T-reg: 9.5 nTPM
  • eosinophil: 9.3 nTPM
  • non-classical monocyte: 9.2 nTPM
  • naive CD8 T-cell: 8.3 nTPM
  • total PBMC: 8.3 nTPM

Brain region

  • cerebral cortex: 44 nTPM
  • hippocampal formation: 44 nTPM
  • choroid plexus: 43 nTPM
  • hypothalamus: 40 nTPM
  • pons: 39 nTPM
  • basal ganglia: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
0.82
DepMap mean gene effect
-0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFYVE27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFYVE27 as an antibody target. Whether an autoantibody or antibody against ZFYVE27 could matter depends on whether native ZFYVE27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFYVE27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFYVE27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZFYVE27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...