Seroatlas · Human Serome Atlas

RAB11FIP4

Rab11 family-interacting protein 4

Also known as: FLJ00131, KIAA1821, MGC11316, RAB11-FIP4, RFIP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86YS3
Gene
RAB11FIP4
Ensembl
ENSG00000131242
Chromosome
17
Canonical length
637 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Connecting piece,Mid piece,Principal piece
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

637 residues, UniProt reviewed canonical sequence.

>Q86YS3|RAB11FIP4
     1  MAGGAGWSGA PAALLRSVRR LREVFEVCGR DPDGFLRVER VAALGLRFGQ GEEVEKLVKY
    61  LDPNDLGRIN FKDFCRGVFA MKGCEELLKD VLSVESAGTL PCAPEIPDCV EQGSEVTGPT
   121  FADGELIPRE PGFFPEDEEE AMTLAPPEGP QELYTDSPME STQSLEGSVG SPAEKDGGLG
   181  GLFLPEDKSL VHTPSMTTSD LSTHSTTSLI SNEEQFEDYG EGDDVDCAPS SPCPDDETRT
   241  NVYSDLGSSV SSSAGQTPRK MRHVYNSELL DVYCSQCCKK INLLNDLEAR LKNLKANSPN
   301  RKISSTAFGR QLMHSSNFSS SNGSTEDLFR DSIDSCDNDI TEKVSFLEKK VTELENDSLT
   361  NGDLKSKLKQ ENTQLVHRVH ELEEMVKDQE TTAEQALEEE ARRHREAYGK LEREKATEVE
   421  LLNARVQQLE EENTELRTTV TRLKSQTEKL DEERQRMSDR LEDTSLRLKD EMDLYKRMMD
   481  KLRQNRLEFQ KEREATQELI EDLRKELEHL QMYKLDCERP GRGRSASSGL GEFNARAREV
   541  ELEHEVKRLK QENYKLRDQN DDLNGQILSL SLYEAKNLFA AQTKAQSLAA EIDTASRDEL
   601  MEALKEQEEI NFRLRQYMDK IILAILDHNP SILEIKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB11FIP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 53 nTPM
  • basal ganglia: 48 nTPM
  • spinal cord: 48 nTPM
  • testis: 47 nTPM
  • hippocampal formation: 45 nTPM
  • cerebral cortex: 44 nTPM

Single-cell type

  • late spermatids: 2,010 nCPM
  • retinal horizontal cells: 403 nCPM
  • early spermatids: 381 nCPM
  • endometrial luminal cells: 109 nCPM
  • retinal ganglion cells: 108 nCPM
  • cytotrophoblasts: 102 nCPM

Immune cell

  • eosinophil: 79 nTPM
  • neutrophil: 41 nTPM
  • non-classical monocyte: 16 nTPM
  • gdT-cell: 14 nTPM
  • intermediate monocyte: 12 nTPM
  • memory CD8 T-cell: 10 nTPM

Brain region

  • white matter: 142 nTPM
  • thalamus: 133 nTPM
  • basal ganglia: 131 nTPM
  • cerebral cortex: 131 nTPM
  • amygdala: 126 nTPM
  • midbrain: 119 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
2.49
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB11FIP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB11FIP4 as an antibody target. Whether an autoantibody or antibody against RAB11FIP4 could matter depends on whether native RAB11FIP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB11FIP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB11FIP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB11FIP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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