Seroatlas · Human Serome Atlas

EVI5

Ecotropic viral integration site 5 protein homolog

Also known as: EVI5_HUMAN, NB4S

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60447
Gene: EVI5
Ensembl: ENSG00000067208
Chromosome: 1
Canonical length: 810 aa
Protein class: Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables GTPase activator activity and small GTPase binding activity. Involved in positive regulation of GTPase activity and retrograde transport, endosome to Golgi. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

810 residues, UniProt reviewed canonical sequence.

>O60447|EVI5
     1  MVTNKMTAAF RNPSGKQVAT DKVAEKLSST LSWVKNTVSH TVSQMASQVA SPSTSLHTTS
    61  SSTTLSTPAL SPSSPSQLSP DDLELLAKLE EQNRLLETDS KSLRSVNGSR RNSGSSLVSS
   121  SSASSNLSHL EEDSWILWGR IVNEWEDVRK KKEKQVKELV HKGIPHHFRA IVWQLLCSAQ
   181  SMPIKDQYSE LLKMTSPCEK LIRRDIARTY PEHNFFKEKD SLGQEVLFNV MKAYSLVDRE
   241  VGYCQGSAFI VGLLLMQMPE EEAFCVFVKL MQDYRLRELF KPSMAELGLC MYQFECMIQE
   301  HLPELFVHFQ SQSFHTSMYA SSWFLTIFLT TFPLPIATRI FDIFMSEGLE IVFRVGLALL
   361  QMNQAELMQL DMEGMLQHFQ KVIPHQFDGV PDKLIQAAYQ VKYNSKKMKK LEKEYTTIKT
   421  KEMEEQVEIK RLRTENRLLK QRIETLEKHK CSSNYNEDFV LQLEKELVQA RLSEAESQCA
   481  LKEMQDKVLD IEKRNNSLPD ENNIARLQEE LIAVKLREAE AIMGLKELRQ QVKDLEEHWQ
   541  RHLARTTGRW KDPPKKNAMN ELQDELMTIR LREAETQAEI REIKQRMMEM ETQNQINSNH
   601  LRRAEQEVIS LQEKVQYLSA QNKGLLTQLS EAKRKQAEIE CKNKEEVMAV RLREADSIAA
   661  VAELRQHIAE LEIQKEEGKL QGQLNKSDSN QYIGELKDQI AELNHELRCL KGQRGFSGQP
   721  PFDGIHIVNH LIGDDESFHS SDEDFIDNSL QETGVGFPLH GKSGSMSLDP AVADGSESET
   781  EDSVLETRES NQVVQKERPP RRRESYSTTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVI5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

placenta: 11 nTPM
liver: 11 nTPM
testis: 8.1 nTPM
parathyroid gland: 7.5 nTPM
adrenal gland: 6.5 nTPM
thyroid gland: 6.3 nTPM

Single-cell type

choroid plexus epithelial cells: 694 nCPM
sertoli cells: 615 nCPM
endometrial ciliated cells: 596 nCPM
ependymal cells: 541 nCPM
adrenal cortex cells: 414 nCPM
foveolar cells: 400 nCPM

Immune cell

non-classical monocyte: 12 nTPM
neutrophil: 10 nTPM
eosinophil: 9.5 nTPM
classical monocyte: 7.6 nTPM
intermediate monocyte: 5.4 nTPM
memory B-cell: 4.3 nTPM

Brain region

choroid plexus: 16 nTPM
spinal cord: 16 nTPM
white matter: 16 nTPM
thalamus: 15 nTPM
midbrain: 14 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EVI5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVI5 as an antibody target. Whether an autoantibody or antibody against EVI5 could matter depends on whether native EVI5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVI5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EVI5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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