Seroatlas · Human Serome Atlas

SLC6A15

Sodium-dependent neutral amino acid transporter B(0)AT2

Also known as: FLJ10316, hv7-3, NTT73, S6A15_HUMAN, SBAT1, V7-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H2J7
Gene
SLC6A15
Ensembl
ENSG00000072041
Chromosome
12
Canonical length
730 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoli,Vesicles

OverviewNCBI Gene

This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

730 residues, UniProt reviewed canonical sequence.

>Q9H2J7|SLC6A15
     1  MPKNSKVVKR ELDDDVTESV KDLLSNEDAA DDAFKTSELI VDGQEEKDTD VEEGSEVEDE
    61  RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL LPYLILLMVI GIPLFFLELS
   121  VGQRIRRGSI GVWNYISPKL GGIGFASCVV CYFVALYYNV IIGWSLFYFS QSFQQPLPWD
   181  QCPLVKNASH TFVEPECEQS SATTYYWYRE ALNISSSISE SGGLNWKMTI CLLAAWVMVC
   241  LAMIKGIQSS GKIIYFSSLF PYVVLICFLI RAFLLNGSID GIRHMFTPKL EIMLEPKVWR
   301  EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL VVFAVLGFKA
   361  NVINEKCITQ NSETIMKFLK MGNISQDIIP HHINLSTVTA EDYHLVYDII QKVKEEEFPA
   421  LHLNSCKIEE ELNKAVQGTG LAFIAFTEAM THFPASPFWS VMFFLMLVNL GLGSMFGTIE
   481  GIVTPIVDTF KVRKEILTVI CCLLAFCIGL IFVQRSGNYF VTMFDDYSAT LPLLIVVILE
   541  NIAVCFVYGI DKFMEDLKDM LGFAPSRYYY YMWKYISPLM LLSLLIASVV NMGLSPPGYN
   601  AWIEDKASEE FLSYPTWGLV VCVSLVVFAI LPVPVVFIVR RFNLIDDSSG NLASVTYKRG
   661  RVLKEPVNLE GDDTSLIHGK IPSEMPSPNF GKNIYRKQSG SPTLDTAPNG RYGIGYLMAD
   721  IMPDMPESDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC6A15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • retina: 15 nTPM
  • cerebral cortex: 13 nTPM
  • hypothalamus: 11 nTPM
  • cerebellum: 9.2 nTPM
  • basal ganglia: 5.1 nTPM
  • midbrain: 5 nTPM

Single-cell type

  • melanocytes: 183 nCPM
  • lactotrophs: 164 nCPM
  • somatotrophs: 95 nCPM
  • retinal pigment epithelial cells: 90 nCPM
  • other brain neurons: 85 nCPM
  • brain excitatory neurons: 74 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 60 nTPM
  • pons: 50 nTPM
  • hypothalamus: 43 nTPM
  • cerebral cortex: 42 nTPM
  • basal ganglia: 31 nTPM
  • medulla oblongata: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0
gnomAD missense Z
1.84
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC6A15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC6A15 as an antibody target. Whether an autoantibody or antibody against SLC6A15 could matter depends on whether native SLC6A15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC6A15 is annotated at the cell surface, where native SLC6A15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC6A15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC6A15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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