Seroatlas · Human Serome Atlas

SLC1A5

Neutral amino acid transporter B(0)

Also known as: AAAT, AAAT_HUMAN, ASCT2, M7V1, RDRC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15758
Gene
SLC1A5
Ensembl
ENSG00000105281
Chromosome
19
Canonical length
541 aa
Protein class
FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Centriolar satellite,Basal body
Quaternary structure
Homotrimer

OverviewNCBI Gene

The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q15758|SLC1A5
     1  MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR ANLLVLLTVV
    61  AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL RMIILPLVVC SLIGGAASLD
   121  PGALGRLGAW ALLFFLVTTL LASALGVGLA LALQPGAASA AINASVGAAG SAENAPSKEV
   181  LDSFLDLARN IFPSNLVSAA FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV
   241  FGVALRKLGP EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA
   301  RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT SSSSATLPLM
   361  MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF IAQLSQQSLD FVKIITILVT
   421  ATASSVGAAG IPAGGVLTLA IILEAVNLPV DHISLILAVD WLVDRSCTVL NVEGDALGAG
   481  LLQNYVDRTE SRSTEPELIQ VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV
   541  M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC1A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
117 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 117 nTPM
  • urinary bladder: 99 nTPM
  • prostate: 95 nTPM
  • esophagus: 94 nTPM
  • epididymis: 93 nTPM
  • adipose tissue: 91 nTPM

Single-cell type

  • prostatic hillock cells: 188 nCPM
  • extravillous trophoblasts: 178 nCPM
  • basal prostatic cells: 158 nCPM
  • urothelial cells: 141 nCPM
  • salivary basal cells: 133 nCPM
  • epididymal principal cells: 132 nCPM

Immune cell

  • plasmacytoid DC: 96 nTPM
  • non-classical monocyte: 67 nTPM
  • intermediate monocyte: 55 nTPM
  • myeloid DC: 50 nTPM
  • classical monocyte: 36 nTPM
  • total PBMC: 28 nTPM

Brain region

  • medulla oblongata: 29 nTPM
  • pons: 21 nTPM
  • white matter: 20 nTPM
  • midbrain: 20 nTPM
  • hypothalamus: 17 nTPM
  • spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.17
gnomAD missense Z
1.86
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC1A5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC1A5 as an antibody target. Whether an autoantibody or antibody against SLC1A5 could matter depends on whether native SLC1A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC1A5 is annotated at the cell surface, where native SLC1A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC1A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC1A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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