Seroatlas · Human Serome Atlas

VAMP8

Vesicle-associated membrane protein 8

Also known as: EDB, VAMP-8, VAMP8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BV40
Gene: VAMP8
Ensembl: ENSG00000118640
Chromosome: 2
Canonical length: 100 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Plasma membrane

OverviewNCBI Gene

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>Q9BV40|VAMP8
     1  MEEASEGGGN DRVRNLQSEV EGVKNIMTQN VERILARGEN LEHLRNKTED LEATSEHFKT
    61  TSQKVARKFW WKNVKMIVLI CVIVFIIILF IVLFATGAFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAMP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 340 nTPM

Expression across tissuesHPA

Tissue

esophagus: 340 nTPM
kidney: 307 nTPM
salivary gland: 303 nTPM
tonsil: 292 nTPM
choroid plexus: 288 nTPM
bone marrow: 283 nTPM

Single-cell type

esophageal apical cells: 2,860 nCPM
esophageal suprabasal cells: 1,460 nCPM
hofbauer cells: 1,457 nCPM
kupffer cells: 1,310 nCPM
cytotrophoblasts: 1,144 nCPM
enterocytes: 1,101 nCPM

Immune cell

plasmacytoid DC: 2,141 nTPM
total PBMC: 1,538 nTPM
classical monocyte: 871 nTPM
myeloid DC: 789 nTPM
intermediate monocyte: 742 nTPM
T-reg: 667 nTPM

Brain region

choroid plexus: 60 nTPM
white matter: 30 nTPM
thalamus: 29 nTPM
medulla oblongata: 28 nTPM
pons: 21 nTPM
spinal cord: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0.11
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAMP8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAMP8 as an antibody target. Whether an autoantibody or antibody against VAMP8 could matter depends on whether native VAMP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAMP8 is annotated at the cell surface, where native VAMP8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VAMP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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