Seroatlas · Human Serome Atlas

EXOC6

Exocyst complex component 6

Also known as: DKFZp761I2124, EXOC6_HUMAN, EXOC6A, FLJ1125, MGC33397, Sec15, SEC15L, SEC15L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAG9
Gene
EXOC6
Ensembl
ENSG00000138190
Chromosome
10
Canonical length
804 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Centrosome,Basal body,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

804 residues, UniProt reviewed canonical sequence.

>Q8TAG9|EXOC6
     1  MAENSESLGT VPEHERILQE IESTDTACVG PTLRSVYDDQ PNAHKKFMEK LDACIRNHDK
    61  EIEKMCNFHH QGFVDAITEL LKVRTDAEKL KVQVTDTNRR FQDAGKEVIV HTEDIIRCRI
   121  QQRNITTVVE KLQLCLPVLE MYSKLKEQMS AKRYYSALKT MEQLENVYFP WVSQYRFCQL
   181  MIENLPKLRE DIKEISMSDL KDFLESIRKH SDKIGETAMK QAQHQKTFSV SLQKQNKMKF
   241  GKNMYINRDR IPEERNETVL KHSLEEEDEN EEEILTVQDL VDFSPVYRCL HIYSVLGDEE
   301  TFENYYRKQR KKQARLVLQP QSNMHETVDG YRRYFTQIVG FFVVEDHILH VTQGLVTRAY
   361  TDELWNMALS KIIAVLRAHS SYCTDPDLVL ELKNLTVIFA DTLQGYGFPV NRLFDLLFEI
   421  RDQYNETLLK KWAGVFRDIF EEDNYSPIPV VNEEEYKIVI SKFPFQDPDL EKQSFPKKFP
   481  MSQSVPHIYI QVKEFIYASL KFSESLHRSS TEIDDMLRKS TNLLLTRTLS SCLLNLIRKP
   541  HIGLTELVQI IINTTHLEQA CKYLEDFITN ITNISQETVH TTRLYGLSTF KDARHAAEGE
   601  IYTKLNQKID EFVQLADYDW TMSEPDGRAS GYLMDLINFL RSIFQVFTHL PGKVAQTACM
   661  SACQHLSTSL MQMLLDSELK QISMGAVQQF NLDVIQCELF ASSEPVPGFQ GDTLQLAFID
   721  LRQLLDLFMV WDWSTYLADY GQPASKYLRV NPNTALTLLE KMKDTSKKNN IFAQFRKNDR
   781  DKQKLIETVV KQLRSLVNGM SQHM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
152 nTPM

Expression across tissuesHPA

Tissue

  • retina: 152 nTPM
  • placenta: 35 nTPM
  • skeletal muscle: 30 nTPM
  • thyroid gland: 27 nTPM
  • tongue: 18 nTPM
  • adrenal gland: 14 nTPM

Single-cell type

  • myonuclei: 1,055 nCPM
  • neutrophils: 876 nCPM
  • sertoli cells: 631 nCPM
  • neutrophil progenitors: 593 nCPM
  • rod photoreceptor cells: 470 nCPM
  • vascular endothelial cells: 331 nCPM

Immune cell

  • neutrophil: 31 nTPM
  • eosinophil: 15 nTPM
  • plasmacytoid DC: 11 nTPM
  • memory B-cell: 6.7 nTPM
  • naive B-cell: 6.6 nTPM
  • basophil: 6.3 nTPM

Brain region

  • cerebral cortex: 26 nTPM
  • cerebellum: 25 nTPM
  • choroid plexus: 25 nTPM
  • hippocampal formation: 23 nTPM
  • white matter: 23 nTPM
  • basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
1.79
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC6 as an antibody target. Whether an autoantibody or antibody against EXOC6 could matter depends on whether native EXOC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXOC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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