Seroatlas · Human Serome Atlas

SGSM1

Small G protein signaling modulator 1

Also known as: KIAA1941, RUTBC2, SGSM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2NKQ1
Gene: SGSM1
Ensembl: ENSG00000167037
Chromosome: 22
Canonical length: 1148 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables GTPase activator activity and small GTPase binding activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle membrane and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1148 residues, UniProt reviewed canonical sequence.

>Q2NKQ1|SGSM1
     1  MASAPAEAET RQRLLRTVKK EVKQIMEEAV TRKFVHEDSS HIISFCAAVE ACVLHGLRRR
    61  AAGFLRSNKI AALFMKVGKN FPPAEDLSRK VQDLEQLIES ARNQIQGLQE NVRKLPKLPN
   121  LSPLAIKHLW IRTALFEKVL DKIVHYLVEN SSKYYEKEAL LMDPVDGPIL ASLLVGPCAL
   181  EYTKMKTADH FWTDPSADEL VQRHRIHSSH VRQDSPTKRP ALCIQKRHSS GSMDDRPSLS
   241  ARDYVESLHQ NSRATLLYGK NNVLVQPRDD MEAVPGYLSL HQTADVMTLK WTPNQLMNGS
   301  VGDLDYEKSV YWDYAMTIRL EEIVYLHCHQ QVDSGGTVVL VSQDGIQRPP FRFPKGGHLL
   361  QFLSCLENGL LPHGQLDPPL WSQRGKGKVF PKLRKRSPQG SAESTSSDKD DDEATDYVFR
   421  IIYPGMQSEF VAPDFLGSTS SVSVGPAWMM VPAGRSMLVV ARGSQWEPAR WDTTLPTPSP
   481  KEQPPMPQDL MDVSVSNLPS LWQPSPRKSS CSSCSQSGSA DGSSTNGCNH ERAPLKLLCD
   541  NMKYQILSRA FYGWLAYCRH LSTVRTHLSA LVNHMIVSPD LPCDAGQGLT ARIWEQYLHD
   601  STSYEEQELL RLIYYGGIQP EIRKAVWPFL LGHYQFGMTE TERKEVDEQI HACYAQTMAE
   661  WLGCEAIVRQ RERESHAAAL AKCSSGASLD SHLHRMLHRD STISNESSQS CSSGRQNIRL
   721  HSDSSSSTQV FESVDEVEQV EAEGRLEEKQ PKIPNGNLVN GTCSPDSGHP SSHNFSSGLS
   781  EHSEPSLSTE DSVLDAQRNT PTVLRPRDGS VDDRQSSEAT TSQDEAPREE LAVQDSLESD
   841  LLANESMDEF MSITGSLDMA LPEKDDVVME GWRSSETEKH GQADSEDNLS EEPEMESLFP
   901  ALASLAVTTS ANEVSPVSSS GVTYSPELLD LYTVNLHRIE KDVQRCDRNY WYFTPANLEK
   961  LRNIMCSYIW QHIEIGYVQG MCDLLAPLLV ILDDEALAFS CFTELMKRMN QNFPHGGAMD
  1021  THFANMRSLI QILDSELFEL MHQNGDYTHF YFCYRWFLLD FKRELVYDDV FLVWETIWAA
  1081  KHVSSAHYVL FIALALVEVY RDIILENNMD FTDIIKFFNE MAERHNTKQV LKLARDLVYK
  1141  VQTLIENK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGSM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 18 nTPM
cerebellum: 16 nTPM
basal ganglia: 14 nTPM
cerebral cortex: 11 nTPM
heart muscle: 11 nTPM
pituitary gland: 9.8 nTPM

Single-cell type

thyrotrophs: 396 nCPM
lactotrophs: 310 nCPM
distal convoluted tubule cells: 165 nCPM
ependymal cells: 163 nCPM
other brain neurons: 149 nCPM
brain inhibitory neurons: 144 nCPM

Immune cell

gdT-cell: 0.4 nTPM
NK-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM

Brain region

hypothalamus: 45 nTPM
pons: 43 nTPM
midbrain: 35 nTPM
basal ganglia: 28 nTPM
cerebral cortex: 26 nTPM
medulla oblongata: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0
gnomAD missense Z: 1.97
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Rab-GAP-TBC domain
RUN domain
Small G protein signalling modulator 1/2, Rab-binding domain
Rab-GAP-TBC domain superfamily
RUN domain superfamily
Small G protein signalling modulator 1/2, PH domain
Rab-GTPase-TBC domain
RUN domain
Rab-binding domain (RBD)
Small G protein signaling modulator 1, RUN domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SGSM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGSM1 as an antibody target. Whether an autoantibody or antibody against SGSM1 could matter depends on whether native SGSM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGSM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SGSM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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