Seroatlas · Human Serome Atlas

SLC35F2

Solute carrier family 35 member F2

Also known as: FLJ13018, S35F2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXU6
Gene: SLC35F2
Ensembl: ENSG00000110660
Chromosome: 11
Canonical length: 374 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q8IXU6|SLC35F2
     1  MEADSPAGPG APEPLAEGAA AEFSSLLRRI KGKLFTWNIL KTIALGQMLS LCICGTAITS
    61  QYLAERYKVN TPMLQSFINY CLLFLIYTVM LAFRSGSDNL LVILKRKWWK YILLGLADVE
   121  ANYVIVRAYQ YTTLTSVQLL DCFGIPVLMA LSWFILHARY RVIHFIAVAV CLLGVGTMVG
   181  ADILAGREDN SGSDVLIGDI LVLLGASLYA ISNVCEEYIV KKLSRQEFLG MVGLFGTIIS
   241  GIQLLIVEYK DIASIHWDWK IALLFVAFAL CMFCLYSFMP LVIKVTSATS VNLGILTADL
   301  YSLFVGLFLF GYKFSGLYIL SFTVIMVGFI LYCSTPTRTA EPAESSVPPV TSIGIDNLGL
   361  KLEENLQETH SAVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35F2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 35 nTPM
prostate: 21 nTPM
skin: 20 nTPM
rectum: 19 nTPM
duodenum: 18 nTPM
colon: 17 nTPM

Single-cell type

basal keratinocytes: 96 nCPM
salivary acinar cells: 93 nCPM
suprabasal keratinocytes: 90 nCPM
plasma cells: 86 nCPM
prostatic glandular cells: 79 nCPM
cone photoreceptor cells: 73 nCPM

Immune cell

T-reg: 13 nTPM
memory B-cell: 11 nTPM
MAIT T-cell: 8.2 nTPM
myeloid DC: 6.9 nTPM
naive B-cell: 6.5 nTPM
memory CD8 T-cell: 5.4 nTPM

Brain region

hypothalamus: 7.7 nTPM
spinal cord: 7.7 nTPM
basal ganglia: 6.6 nTPM
hippocampal formation: 6.4 nTPM
white matter: 6.4 nTPM
medulla oblongata: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC35F2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAB11A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35F2 as an antibody target. Whether an autoantibody or antibody against SLC35F2 could matter depends on whether native SLC35F2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35F2 is annotated at the cell surface, where native SLC35F2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC35F2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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