Seroatlas · Human Serome Atlas

STXBP6

Syntaxin-binding protein 6

Also known as: amisyn, HSPC156, STXB6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFX7
Gene: STXBP6
Ensembl: ENSG00000168952
Chromosome: 14
Canonical length: 210 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables cadherin binding activity involved in cell-cell adhesion. Predicted to be involved in negative regulation of exocytosis. Located in adherens junction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>Q8NFX7|STXBP6
     1  MSAKSAISKE IFAPLDERML GAVQVKRRTK KKIPFLATGG QGEYLTYICL SVTNKKPTQA
    61  SITKVKQFEG STSFVRRSQW MLEQLRQVNG IDPNGDSAEF DLLFENAFDQ WVASTASEKC
   121  TFFQILHHTC QRYLTDRKPE FINCQSKIMG GNSILHSAAD SVTSAVQKAS QALNERGERL
   181  GRAEEKTEDL KNSAQQFAET AHKLAMKHKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STXBP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

placenta: 40 nTPM
pancreas: 37 nTPM
epididymis: 36 nTPM
lung: 24 nTPM
heart muscle: 23 nTPM
basal ganglia: 22 nTPM

Single-cell type

mast cells: 462 nCPM
pancreatic acinar cells: 371 nCPM
melanocytes: 357 nCPM
goblet cells: 299 nCPM
epididymal clear cells: 298 nCPM
oligodendrocytes: 260 nCPM

Immune cell

gdT-cell: 1.1 nTPM
plasmacytoid DC: 0.6 nTPM
naive CD8 T-cell: 0.4 nTPM
MAIT T-cell: 0.2 nTPM
total PBMC: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

thalamus: 95 nTPM
cerebral cortex: 65 nTPM
medulla oblongata: 58 nTPM
midbrain: 57 nTPM
hypothalamus: 53 nTPM
basal ganglia: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cadherin binding involved in cell-cell adhesion

Cellular components

Protein domainsUniProt · Pfam · InterPro

Exocyst complex component Sec3, PIP2-binding N-terminal domain
v-SNARE, coiled-coil homology domain
Synaptobrevin
Exocyst complex component SEC3 N-terminal PIP2 binding PH
Syntaxin-binding protein 6, PH domain
STXBP6, SNARE domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STXBP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STXBP6 as an antibody target. Whether an autoantibody or antibody against STXBP6 could matter depends on whether native STXBP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STXBP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STXBP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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