Seroatlas · Human Serome Atlas

TBC1D12

TBC1 domain family member 12

Also known as: KIAA0608, TBC12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60347
Gene: TBC1D12
Ensembl: ENSG00000108239
Chromosome: 10
Canonical length: 775 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be involved in regulation of autophagosome assembly. Predicted to be located in endosome. Predicted to be active in autophagosome and recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

775 residues, UniProt reviewed canonical sequence.

>O60347|TBC1D12
     1  MVGPEDAGAC SGRNPKLLPV PAPDPVGQDR KVIRATGGFG GGVGAVEPPE EADEEEEADE
    61  EEETPPRQLL QRYLAAAGEQ LEPGLCYCPL PAGQAGAPPP SAAPRSDACL LGSGSKHRGA
   121  EVADGRAPRH EGMTNGDSGF LPGRDCRDLE EARGLARAGG RESRRRRPYG RLRLEGPGDE
   181  DADGAGSPSD WASPLEDPLR SCCLVAADAQ EPEGAGSDSG DSPASSCSSS EDSEQRGVGA
   241  GGPEEGAPPA TSAERTNGGA EPRLGFSDIH FNSRNTFQVS RGQSARDHLP PAGPPVPLPA
   301  AEQGPAGASA RARRSGGFAD FFTRNLFPKR TKELKSVVHS APGWKLFGKV PPRENLQKTS
   361  KIIQQEYEAR TGRTCKPPPQ SSRRKNFEFE PLSTTALILE DRPSNLPAKS VEEALRHRQE
   421  YDEMVAEAKK REIKEAHKRK RIMKERFKQE ENIASAMVIW INEILPNWEV MRSTRRVREL
   481  WWQGLPPSVR GKVWSLAVGN ELNITPELYE IFLSRAKERW KSFSETSSEN DTEGVSVADR
   541  EASLELIKLD ISRTFPSLYI FQKGGPYHDV LHSILGAYTC YRPDVGYVQG MSFIAAVLIL
   601  NLEEADAFIA FANLLNKPCQ LAFFRVDHSM MLKYFATFEV FFEENLSKLF LHFKSYSLTP
   661  DIYLIDWIFT LYSKSLPLDL ACRVWDVFCR DGEEFLFRTG LGILRLYEDI LLQMDFIHIA
   721  QFLTKLPEDI TSEKLFSCIA AIQMQNSTKK WTQVFASVMK DIKEGDKNSS PALKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 41 nTPM
midbrain: 17 nTPM
parathyroid gland: 13 nTPM
hippocampal formation: 11 nTPM
cerebral cortex: 9.3 nTPM
basal ganglia: 8 nTPM

Single-cell type

microglia: 305 nCPM
oligodendrocytes: 274 nCPM
fibro-adipogenic progenitors: 210 nCPM
macrophages: 177 nCPM
kupffer cells: 163 nCPM
rod photoreceptor cells: 152 nCPM

Immune cell

myeloid DC: 0.4 nTPM
classical monocyte: 0.2 nTPM
naive B-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

white matter: 91 nTPM
medulla oblongata: 83 nTPM
cerebellum: 57 nTPM
pons: 55 nTPM
midbrain: 54 nTPM
basal ganglia: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAB11A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D12 as an antibody target. Whether an autoantibody or antibody against TBC1D12 could matter depends on whether native TBC1D12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...