Seroatlas · Human Serome Atlas

CHML

Rab proteins geranylgeranyltransferase component A 2

Also known as: RAE2_HUMAN, REP-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26374
Gene
CHML
Ensembl
ENSG00000203668
Chromosome
1
Canonical length
656 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

656 residues, UniProt reviewed canonical sequence.

>P26374|CHML
     1  MADNLPTEFD VVIIGTGLPE SILAAACSRS GQRVLHIDSR SYYGGNWASF SFSGLLSWLK
    61  EYQQNNDIGE ESTVVWQDLI HETEEAITLR KKDETIQHTE AFCYASQDME DNVEEIGALQ
   121  KNPSLGVSNT FTEVLDSALP EESQLSYFNS DEMPAKHTQK SDTEISLEVT DVEESVEKEK
   181  YCGDKTCMHT VSDKDGDKDE SKSTVEDKAD EPIRNRITYS QIVKEGRRFN IDLVSKLLYS
   241  QGLLIDLLIK SDVSRYVEFK NVTRILAFRE GKVEQVPCSR ADVFNSKELT MVEKRMLMKF
   301  LTFCLEYEQH PDEYQAFRQC SFSEYLKTKK LTPNLQHFVL HSIAMTSESS CTTIDGLNAT
   361  KNFLQCLGRF GNTPFLFPLY GQGEIPQGFC RMCAVFGGIY CLRHKVQCFV VDKESGRCKA
   421  IIDHFGQRIN AKYFIVEDSY LSEETCSNVQ YKQISRAVLI TDQSILKTDL DQQTSILIVP
   481  PAEPGACAVR VTELCSSTMT CMKDTYLVHL TCSSSKTARE DLESVVKKLF TPYTETEINE
   541  EELTKPRLLW ALYFNMRDSS GISRSSYNGL PSNVYVCSGP DCGLGNEHAV KQAETLFQEI
   601  FPTEEFCPPP PNPEDIIFDG DDKQPEAPGT NNVVMAKLES SEESKNLESP EKHLQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHML can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 11 nTPM
  • bone marrow: 7 nTPM
  • ovary: 6 nTPM
  • thymus: 5.9 nTPM
  • cerebral cortex: 5.8 nTPM
  • testis: 5.7 nTPM

Single-cell type

  • late spermatids: 15 nCPM
  • megakaryocytes: 12 nCPM
  • erythrocyte progenitors: 10 nCPM
  • megakaryocyte progenitors: 9 nCPM
  • extravillous trophoblasts: 8.4 nCPM
  • megakaryocyte-erythroid progenitors: 8.2 nCPM

Immune cell

  • basophil: 1.1 nTPM
  • plasmacytoid DC: 0.7 nTPM
  • intermediate monocyte: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • naive CD4 T-cell: 0.3 nTPM

Brain region

  • cerebral cortex: 17 nTPM
  • white matter: 13 nTPM
  • thalamus: 12 nTPM
  • basal ganglia: 12 nTPM
  • midbrain: 11 nTPM
  • amygdala: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
-0.04
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHML in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHML as an antibody target. Whether an autoantibody or antibody against CHML could matter depends on whether native CHML is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHML is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHML as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHML. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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