Seroatlas · Human Serome Atlas

VAMP3

Vesicle-associated membrane protein 3

Also known as: CEB, VAMP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15836
Gene
VAMP3
Ensembl
ENSG00000049245
Chromosome
1
Canonical length
100 aa
Protein class
Cancer-related genes, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>Q15836|VAMP3
     1  MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA DALQAGASQF
    61  ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAMP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
185 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 185 nTPM
  • midbrain: 109 nTPM
  • bone marrow: 107 nTPM
  • blood vessel: 107 nTPM
  • adipose tissue: 102 nTPM
  • tongue: 92 nTPM

Single-cell type

  • esophageal apical cells: 298 nCPM
  • extravillous trophoblasts: 155 nCPM
  • esophageal suprabasal cells: 151 nCPM
  • megakaryocytes: 148 nCPM
  • syncytiotrophoblasts: 132 nCPM
  • oocytes: 106 nCPM

Immune cell

  • neutrophil: 85 nTPM
  • intermediate monocyte: 72 nTPM
  • non-classical monocyte: 65 nTPM
  • basophil: 64 nTPM
  • eosinophil: 63 nTPM
  • classical monocyte: 63 nTPM

Brain region

  • white matter: 155 nTPM
  • medulla oblongata: 135 nTPM
  • midbrain: 115 nTPM
  • basal ganglia: 114 nTPM
  • cerebellum: 113 nTPM
  • spinal cord: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAMP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAMP3 as an antibody target. Whether an autoantibody or antibody against VAMP3 could matter depends on whether native VAMP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAMP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VAMP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VAMP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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