Seroatlas · Human Serome Atlas

RAB11FIP3

Rab11 family-interacting protein 3

Also known as: eferin, KIAA0665, Rab11-FIP3, RFIP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75154
Gene
RAB11FIP3
Ensembl
ENSG00000090565
Chromosome
16
Canonical length
756 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Cytokinetic bridge,Primary cilium,Centriolar satellite,Basal body
Quaternary structure
Homodimer

OverviewNCBI Gene

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

756 residues, UniProt reviewed canonical sequence.

>O75154|RAB11FIP3
     1  MASAPPASPP GSEPPGPDPE PGGPDGPGAA QLAPGPAELR LGAPVGGPDP QSPGLDEPAP
    61  GAAADGGARW SAGPAPGLEG GPRDPGPSAP PPRSGPRGQL ASPDAPGPGP RSEAPLPELD
   121  PLFSWTEEPE ECGPASCPES APFRLQGSSS SHRARGEVDV FSPFPAPTAG ELALEQGPGS
   181  PPQPSDLSQT HPLPSEPVGS QEDGPRLRAV FDALDGDGDG FVRIEDFIQF ATVYGAEQVK
   241  DLTKYLDPSG LGVISFEDFY QGITAIRNGD PDGQCYGGVA SAQDEEPLAC PDEFDDFVTY
   301  EANEVTDSAY MGSESTYSEC ETFTDEDTST LVHPELQPEG DADSAGGSAV PSECLDAMEE
   361  PDHGALLLLP GRPHPHGQSV ITVIGGEEHF EDYGEGSEAE LSPETLCNGQ LGCSDPAFLT
   421  PSPTKRLSSK KVARYLHQSG ALTMEALEDP SPELMEGPEE DIADKVVFLE RRVLELEKDT
   481  AATGEQHSRL RQENLQLVHR ANALEEQLKE QELRACEMVL EETRRQKELL CKMEREKSIE
   541  IENLQTRLQQ LDEENSELRS CTPCLKANIE RLEEEKQKLL DEIESLTLRL SEEQENKRRM
   601  GDRLSHERHQ FQRDKEATQE LIEDLRKQLE HLQLLKLEAE QRRGRSSSMG LQEYHSRARE
   661  SELEQEVRRL KQDNRNLKEQ NEELNGQIIT LSIQGAKSLF STAFSESLAA EISSVSRDEL
   721  MEAIQKQEEI NFRLQDYIDR IIVAIMETNP SILEVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB11FIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
151 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 151 nTPM
  • cerebellum: 67 nTPM
  • cerebral cortex: 66 nTPM
  • hippocampal formation: 52 nTPM
  • skeletal muscle: 50 nTPM
  • amygdala: 49 nTPM

Single-cell type

  • proximal tubule cells: 1,639 nCPM
  • renal connecting tubule cells: 208 nCPM
  • loop of henle epithelial cells: 188 nCPM
  • distal convoluted tubule cells: 172 nCPM
  • renal collecting duct intercalated cells: 160 nCPM
  • brain excitatory neurons: 107 nCPM

Immune cell

  • gdT-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 58 nTPM
  • hippocampal formation: 49 nTPM
  • white matter: 39 nTPM
  • cerebellum: 39 nTPM
  • midbrain: 39 nTPM
  • basal ganglia: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
1.27
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB11FIP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB11FIP3 as an antibody target. Whether an autoantibody or antibody against RAB11FIP3 could matter depends on whether native RAB11FIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB11FIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB11FIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB11FIP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...