Seroatlas · Human Serome Atlas

SCAMP1

Secretory carrier-associated membrane protein 1

Also known as: SCAM1_HUMAN, SCAMP37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15126
Gene
SCAMP1
Ensembl
ENSG00000085365
Chromosome
5
Canonical length
338 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles,Cell Junctions

OverviewNCBI Gene

This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>O15126|SCAMP1
     1  MSDFDSNPFA DPDLNNPFKD PSVTQVTRNV PPGLDEYNPF SDSRTPPPGG VKMPNVPNTQ
    61  PAIMKPTEEH PAYTQIAKEH ALAQAELLKR QEELERKAAE LDRREREMQN LSQHGRKNNW
   121  PPLPSNFPVG PCFYQDFSVD IPVEFQKTVK LMYYLWMFHA VTLFLNIFGC LAWFCVDSAR
   181  AVDFGLSILW FLLFTPCSFV CWYRPLYGAF RSDSSFRFFV FFFVYICQFA VHVLQAAGFH
   241  NWGNCGWISS LTGLNQNIPV GIMMIIIAAL FTASAVISLV MFKKVHGLYR TTGASFEKAQ
   301  QEFATGVMSN KTVQTAAANA ASTAASSAAQ NAFKGNQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCAMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 44 nTPM
  • cerebral cortex: 41 nTPM
  • thyroid gland: 37 nTPM
  • retina: 37 nTPM
  • prostate: 32 nTPM
  • salivary gland: 30 nTPM

Single-cell type

  • cone photoreceptor cells: 209 nCPM
  • retinal pigment epithelial cells: 200 nCPM
  • thyrotrophs: 189 nCPM
  • bergmann glia: 186 nCPM
  • corticotrophs: 159 nCPM
  • lactotrophs: 154 nCPM

Immune cell

  • basophil: 20 nTPM
  • non-classical monocyte: 17 nTPM
  • myeloid DC: 15 nTPM
  • eosinophil: 13 nTPM
  • intermediate monocyte: 13 nTPM
  • classical monocyte: 11 nTPM

Brain region

  • cerebellum: 61 nTPM
  • choroid plexus: 61 nTPM
  • thalamus: 60 nTPM
  • cerebral cortex: 59 nTPM
  • hypothalamus: 57 nTPM
  • pons: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.42

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCAMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCAMP1 as an antibody target. Whether an autoantibody or antibody against SCAMP1 could matter depends on whether native SCAMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCAMP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCAMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCAMP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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