Seroatlas · Human Serome Atlas

GPRC5C

G-protein coupled receptor family C group 5 member C

Also known as: GPC5C_HUMAN, RAIG-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQ84
Gene
GPRC5C
Ensembl
ENSG00000170412
Chromosome
17
Canonical length
441 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Primary cilium,Primary cilium transition zone,Centriolar satellite

OverviewNCBI Gene

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q9NQ84|GPRC5C
     1  MAIHKALVMC LGLPLFLFPG AWAQGHVPPG CSQGLNPLYY NLCDRSGAWG IVLEAVAGAG
    61  IVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL FCLVFACVVK PDFSTCASRR
   121  FLFGVLFAIC FSCLAAHVFA LNFLARKNHG PRGWVIFTVA LLLTLVEVII NTEWLIITLV
   181  RGSGEGGPQG NSSAGWAVAS PCAIANMDFV MALIYVMLLL LGAFLGAWPA LCGRYKRWRK
   241  HGVFVLLTTA TSVAIWVVWI VMYTYGNKQH NSPTWDDPTL AIALAANAWA FVLFYVIPEV
   301  SQVTKSSPEQ SYQGDMYPTR GVGYETILKE QKGQSMFVEN KAFSMDEPVA AKRPVSPYSG
   361  YNGQLLTSVY QPTEMALMHK VPSEGAYDII LPRATANSQV MGSANSTLRA EDMYSAQSHQ
   421  AATPPKDGKN SQVFRNPYVW D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRC5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
180 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 180 nTPM
  • liver: 163 nTPM
  • pancreas: 128 nTPM
  • kidney: 105 nTPM
  • skeletal muscle: 86 nTPM
  • cerebellum: 80 nTPM

Single-cell type

  • conjunctival goblet cells: 227 nCPM
  • parietal cells: 223 nCPM
  • gastric chief cells: 217 nCPM
  • hepatocytes: 207 nCPM
  • endometrial secretory cells: 191 nCPM
  • salivary duct cells: 157 nCPM

Immune cell

  • plasmacytoid DC: 7.9 nTPM
  • non-classical monocyte: 3.8 nTPM
  • intermediate monocyte: 2.5 nTPM
  • myeloid DC: 1.8 nTPM
  • classical monocyte: 1.1 nTPM
  • memory B-cell: 0.6 nTPM

Brain region

  • cerebellum: 84 nTPM
  • choroid plexus: 41 nTPM
  • midbrain: 22 nTPM
  • pons: 22 nTPM
  • basal ganglia: 21 nTPM
  • medulla oblongata: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPRC5C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRC5C as an antibody target. Whether an autoantibody or antibody against GPRC5C could matter depends on whether native GPRC5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRC5C is annotated at the cell surface, where native GPRC5C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPRC5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPRC5C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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