Seroatlas · Human Serome Atlas

NUP93

Nuclear pore complex protein Nup93

Also known as: KIAA0095, NUP93_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N1F7
Gene
NUP93
Ensembl
ENSG00000102900
Chromosome
16
Canonical length
819 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

819 residues, UniProt reviewed canonical sequence.

>Q8N1F7|NUP93
     1  MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA
    61  SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR
   121  TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYISDV GPPGRSSLDN
   181  IEMAYARQIY IYNEKIVNGH LQPNLVDLCA SVAELDDKSI SDMWTMVKQM TDVLLTPATD
   241  ALKNRSSVEV RMEFVRQALA YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK
   301  LPAPLPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVNR AQHQLGEFKT WFQEYMNSKD
   361  RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDVT DNQSEVADKT EDYLWLKLNQ
   421  VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAVAFLF
   481  RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCLRRLNFVR LLMLYTRKFE
   541  STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK
   601  FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK
   661  ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIERLKLV
   721  PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS SSRPQRVIED
   781  RDSQLRSQAR TLITFAGMIP YRTSGDTNAR LVQMEVLMN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP93 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 50 nTPM
  • testis: 37 nTPM
  • thyroid gland: 32 nTPM
  • thymus: 32 nTPM
  • retina: 29 nTPM
  • tonsil: 28 nTPM

Single-cell type

  • oocytes: 230 nCPM
  • retinal bipolar cells: 174 nCPM
  • brain inhibitory neurons: 121 nCPM
  • retinal ganglion cells: 112 nCPM
  • erythrocyte progenitors: 103 nCPM
  • differentiating spermatogonia: 97 nCPM

Immune cell

  • eosinophil: 197 nTPM
  • non-classical monocyte: 78 nTPM
  • intermediate monocyte: 78 nTPM
  • myeloid DC: 61 nTPM
  • NK-cell: 52 nTPM
  • classical monocyte: 50 nTPM

Brain region

  • hippocampal formation: 99 nTPM
  • cerebral cortex: 84 nTPM
  • basal ganglia: 71 nTPM
  • thalamus: 59 nTPM
  • hypothalamus: 58 nTPM
  • medulla oblongata: 57 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP93.

Disease | AllUniProt

Conditions NUP93 is implicated in, by any mechanism.

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 342 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0
gnomAD missense Z
1.3
DepMap mean gene effect
-1.62
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Nucleoporin interacting component Nup93/Nic96
  • Nup93/Nic96

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP93 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP93 as an antibody target. Whether an autoantibody or antibody against NUP93 could matter depends on whether native NUP93 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP93 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP93 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUP93. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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